Belliato, Mirko and Cremascoli, Luca and Epis, Francesco and Ferrari, Fiorenza and Quattrone, Maria G. and Malfertheiner, Maximilian and Broman, Lars M. and Aliberti, Anna and Taccone, Fabio S. and Iotti, Giorgio A. and Lorusso, Roberto (2021) Carbon Dioxide Elimination During Veno-Venous Extracorporeal Membrane Oxygenation Weaning: A Pilot Study. ASAIO JOURNAL, 67 (6). pp. 700-708. ISSN 1058-2916, 1538-943X
Full text not available from this repository. (Request a copy)Abstract
Veno-venous extracorporeal membrane oxygenation (V-V ECMO) represents a component of the treatment strategy for severe respiratory failure. Clinical evidence on the management of the lung during V-V ECMO are limited just as the consensus regarding timing of weaning. The monitoring of the carbon dioxide (CO2) removal (V ' CO2TOT) is subdivided into two components: the membrane lung (ML) and the native lung (NL) are both taken into consideration to evaluate the improvement of the function of the lung and to predict the time to wean off ECMO. We enrolled patients with acute respiratory distress syndrome (ARDS). The V ' CO2NL ratio (V ' CO2NL/V ' CO2TOT) value was calculated based on the distribution of CO2 between the NL and the ML. Of 18 patients, 15 were successfully weaned off of V-V ECMO. In this subgroup, we observed a significant increase in the V ' CO2NL ratio comparing the median values of the first and last quartiles (0.32 vs. 0.53, p = 0.0045), without observing any modifications in the ventilation parameters. An increase in the V ' CO2NL ratio, independently from any change in ventilation could, despite the limitations of the study, indicate an improvement in pulmonary function and may be used as a weaning index for ECMO.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VOLUMETRIC CAPNOGRAPHY; GAS-EXCHANGE; DEAD-SPACE; MECHANICAL VENTILATION; LUNG INJURY; LESSONS; SUPPORT; ECMO; acute respiratory distress syndrome; mechanical ventilation; veno-venous extracorporeal membrane oxygenation; extracorporeal carbon dioxide removal; extracorporeal membrane oxygenation weaning |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Sep 2022 06:25 |
| Last Modified: | 23 Sep 2022 06:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47906 |
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