SCHWARZ, W and HARTMANN, RW and SCHONENBERGER, H (1991) 1,2-DIPHENYL-1-PYRIDYL-BUT-1-ENES - POTENTIAL ANTIESTROGENS .1. SYNTHESIS. ARCHIV DER PHARMAZIE, 324 (4). pp. 223-229. ISSN 0365-6233,
Full text not available from this repository.Abstract
The synthesis of the potentially antiestrogenic 1,2-diphenyl-1-pyridyl-but-1-enes is reported. The key compounds 1-(4-methoxyphenyl)-1-(4- resp. 3-pyridyl)-2-phenyl-but-1-ene (E/Z-1c resp. E/Z-2c) were prepared by coupling of the corresponding 4-methoxyphenylpyridylketone with propiophenone using TCl4/Zn as the reducing agent. Ether cleavage yielded the phenols 1 and 2, which were either reacted with 2-dimethylamino-ethylchloride to give the Tam-analogues 1b,o and 2b,o or transformed into the derivatives 1a and 2b by acetylation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACETOXY-SUBSTITUTED 1,1,2-TRIPHENYLBUT-1-ENES; ESTRADIOL-RECEPTOR AFFINITY; TUMOR INHIBITING PROPERTIES; BREAST-CANCER-CELLS; ESTROGEN-RECEPTOR; ANTI-ESTROGENS; TAMOXIFEN; CARBONYLS; ISOMERS; OLEFINS; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/55029 |
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