KEES, F and NABER, KG (1990) PHARMACOKINETICS OF CEFIXIME IN VOLUNTEERS COMPARED WITH NEWER ESTER PRO-DRUG CEPHALOSPORINS. INFECTION, 18. S150-S154. ISSN 0300-8126,
Full text not available from this repository.Abstract
The pharmacokinetic parameters of cefixime were determined in healthy volunteers following oral administration of 200 mg cefixime as tablet, syrup and dry suspension, respectively. All three galenic formulations showed reliable absorption. Mean peak plasma concentrations amounted to 2.4-3.4 mg/l and were reached after 3.3-3.5 h. Mean terminal half-lives were 2.9-3.1 h. The mean areas under the plasma concentration-time curves ranged between 18 and 26 mg/l.h; 18-24% of the dose administered were recovered unchanged in the urine. The best bioavailability was obained with the dry suspension followed by the tablet and the syrup. With respect to the ester pro-drug cephalosporins, cefuroxime axetil, cefetamet pivoxyl and cefotiam hexetil, cefixime exhibits higher plasma half-life and area under the curve as well as, comparable absolute bioavailability but consistently lower urinary recovery which indicates higher non-renal clearance.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BETA-LACTAM ANTIBIOTICS; BRUSH-BORDER MEMBRANE; CEFETAMET PIVOXIL RO-15-8075; ABSOLUTE BIOAVAILABILITY; HEALTHY-VOLUNTEERS; CEFUROXIME AXETIL; TRANSPORT; DIPEPTIDES; VESICLES; HUMANS; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/55577 |
Actions (login required)
 |
View Item |
