Badawy, Amr and Brunner, Stefan M. and Knoppke, Birgit and Volkl, Melanie and Junger, Henrik and Loss, Martin and Sinner, Barbara and Huf, Veronika and Grothues, Dirk and Melter, Michael and Schlitt, Hans J. (2022) Predictors of portal vein complications after pediatric liver transplantation: A German center experience. PEDIATRIC TRANSPLANTATION, 26 (5): e14298. ISSN 1397-3142, 1399-3046
Full text not available from this repository. (Request a copy)Abstract
Background Portal vein complications (PVCs) after pediatric liver transplantation (LT) are sometimes asymptomatic, especially in the early phase, and can threaten both the graft and patient's survival. Therefore, the purpose of this study is to analyze the risk factors for portal vein thrombosis (PVT) and portal vein stenosis (PVS) after pediatric LT. Methods All pediatric patients (n = 115) who underwent primary LT at Regensburg University Hospital between January 2010 and April 2017 were included in this study. The pre-, intra-, and postoperative parameters of all patients were retrospectively reviewed and risk factors for both PVT and PVS were analyzed. Results Of the 115 patients, living donor LT was performed on 57 (49.5%) patients, and biliary atresia was the primary diagnosis in 65 patients (56%). After pediatric LT, 9% of patients developed PVT, and 16.5% developed PVS. Patient weight <= 7 kg [odds ratio (OR) 9.35, 95% confidence interval (CI) 1.03-84.9, p = .04] and GRWR >3% (OR 15.4, 95% CI 1.98-129.5, p = .01) were the independent risk factors for the development of PVT and PVS, respectively upon multivariate analysis. The overall patient survival rates at 1, 3, and 5 years were 91%, 90%, and 89%, respectively, and there was no difference in patient survival among those with and without PVCs. Conclusions Pediatric patients with body weight 3% may develop PVCs and so require certain surgical modifications, close follow-up, and prophylactic anticoagulant therapy following transplant.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LEFT LATERAL SEGMENT; RISK-FACTORS; THROMBOSIS; INTERVENTION; MANAGEMENT; OCCLUSION; STENOSIS; GRAFTS; liver transplant; pediatric; portal vein stenosis; portal vein thrombosis; risk factors |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Kinder- und Jugendmedizin Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Feb 2024 07:34 |
| Last Modified: | 13 Feb 2024 07:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56575 |
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