Denzinger, Markus and Schenk, Katharina B. M. and Krauss, Sabrina and Held, Manuel and Daigeler, Adrien and Wolfertstetter, Patricia Reis and Knorr, Christian and Illg, Claudius and Eisler, Wiebke (2022) Immune-modulating properties of blue light do not influence reepithelization in vitro. LASERS IN MEDICAL SCIENCE, 37 (5). pp. 2431-2437. ISSN 0268-8921, 1435-604X
Full text not available from this repository. (Request a copy)Abstract
Phototherapy is gaining more attention in the treatment of various diseases. Especially, blue light seems to be a promising approach for wound healing promotion due to its antimicrobial and immune-modulating properties. Despite this, there is only little research focusing on the immune-modulating properties of blue light and its possible effects on wound healing. Therefore, we investigated the effects of blue light irradiation on peripheral blood mononuclear cells (PBMC) and the influence on reepithelization in vitro. PBMCs were irradiated with DermoDyne (R) (DermoDyne HealthCare, Berlin, Germany) and effects on cell viability, cytokine expression, and scratch wound closure were evaluated afterwards. Irradiated cells showed a higher Interleukin-gamma concentration while irradiation reduced resazurin concentration in a time-dependent manner. No differences in reepithelization were detectable when keratinocytes were treated with the supernatant of these blue light irradiated PBMCs. Blue light-mediated ex vivo stimulation of PBMCs does not cause faster reepithelization in an in vitro setting. Further research is needed to investigate the wound healing effects of phototherapy with blue light.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LEVEL LASER THERAPY; STAPHYLOCOCCUS-AUREUS; PHOTOTHERAPY; MIGRATION; BIOSTIMULATION; PROLIFERATION; PIGMENTATION; IRRADIATION; SUPPRESSES; INFECTION; Wound healing; Phototherapy; Keratinocytes; Scratch assay; PBMC |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Feb 2024 16:16 |
| Last Modified: | 08 Feb 2024 16:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57357 |
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