Einhauser, Sebastian and Peterhoff, David and Beileke, Stephanie and Guenther, Felix and Niller, Hans-Helmut and Steininger, Philipp and Knoell, Antje and Korn, Klaus and Berr, Melanie and Schuetz, Anja and Wiegrebe, Simon and Stark, Klaus J. and Gessner, Andre and Burkhardt, Ralph and Kabesch, Michael and Schedl, Holger and Kuechenhoff, Helmut and Pfahlberg, Annette B. and Heid, Iris M. and Gefeller, Olaf and Ueberla, Klaus and Wagner, Ralf (2022) Time Trend in SARS-CoV-2 Seropositivity, Surveillance Detection- and Infection Fatality Ratio until Spring 2021 in the Tirschenreuth County-Results from a Population-Based Longitudinal Study in Germany. VIRUSES-BASEL, 14 (6): 1168. ISSN , 1999-4915
Full text not available from this repository. (Request a copy)Abstract
Herein, we provide results from a prospective population-based longitudinal follow-up (FU) SARS-CoV-2 serosurveillance study in Tirschenreuth, the county which was hit hardest in Germany in spring 2020 and early 2021. Of 4203 individuals aged 14 years or older enrolled at baseline (BL, June 2020), 3546 participated at FU1 (November 2020) and 3391 at FU2 (April 2021). Key metrics comprising standardized seroprevalence, surveillance detection ratio (SDR), infection fatality ratio (IFR) and success of the vaccination campaign were derived using the Roche N- and S-Elecsys anti-SARS-CoV-2 test together with a self-administered questionnaire. N-seropositivity at BL was 9.2% (1st wave). While we observed a low new seropositivity between BL and FU1 (0.9%), the combined 2nd and 3rd wave accounted for 6.1% new N-seropositives between FU1 and FU2 (ever seropositives at FU2: 15.4%). The SDR decreased from 5.4 (BL) to 1.1 (FU2) highlighting the success of massively increased testing in the population. The IFR based on a combination of serology and registration data resulted in 3.3% between November 2020 and April 2021 compared to 2.3% until June 2020. Although IFRs were consistently higher at FU2 compared to BL across age-groups, highest among individuals aged 70+ (18.3% versus 10.7%, respectively), observed differences were within statistical uncertainty bounds. While municipalities with senior care homes showed a higher IFR at BL (3.0% with senior care home vs. 0.7% w/o), this effect diminished at FU2 (3.4% vs. 2.9%). In April 2021 (FU2), vaccination rate in the elderly was high (>77.4%, age-group 80+).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IMMUNOGENICITY; IMPACT; SARS-CoV-2; seroprevalence; infection fatality ratio; case fatality ratio; surveillance detection ratio; senior care homes; elderly; vaccination; population-based; longitudinal |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Feb 2024 10:36 |
| Last Modified: | 14 Feb 2024 10:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/57378 |
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