Lange, Lars and Gernert, Sunhild and Berger, Moritz and Arens, Alisa and Rache, Luzie and Delissen, Julia and Yavuz, S. Tolga and Millner-Uhlemann, Martina and Wiesenacker, David and Neustadter, Irena and Reese, Imke and Utz, Philipp and Schuster, Antje and Adelsberger, Deborah and Ziegert, Mandy and Kerzel, Sebastian and Finger, Antje (2022) Different Patterns of Foods Triggering FPIES in Germany. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 10 (4). pp. 1063-1069. ISSN 2213-2198, 2213-2201
Full text not available from this repository. (Request a copy)Abstract
BACKGROUND: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated gastrointestinal food allergy mainly affecting infants and young children. Allergic FPIES reactions differ from IgE-mediated food allergies, for example, regarding elicitors and clinical course. OBJECTIVE: The aim of our study was to describe causative agents and development of tolerance in German children with FPIES. METHODS: We conducted a retrospective survey on children with FPIES from 14 centers in Germany assessing a 6-year period. RESULTS: We analyzed 142 patients with 190 FPIES reactions, 130 of which met acute FPIES criteria and 60 were defined as chronic FPIES. The most frequent eliciting food for acute FPIES was cow's milk, followed by fish, vegetables (eg, potato, pumpkin), meats (eg, beef), and grains. A total of 119 children reacted to 1 food only, 16 children to 2 or 3 foods, and 7 children to >= 4 foods. In chronic FPIES, all but 4 exclusively breastfed infants reacted to cow's milk feeding. IgE sensitization to the triggering food was found in 21 of 152 (14%) cases. Two children developed additional IgE-mediated symptoms upon a food challenge. Time to proof of tolerance was shortest in cow's milk-induced FPIES, and it was shorter in chronic than in acute FPIES. CONCLUSION: In our national survey, we identified triggers for acute FPIES that partially differ from those reported internationally. Mainly foods introduced early in infant nutrition triggered acute reactions. Time to proven tolerance was shown to be contingent on FPIES symptomatology and on the triggering food. These data should be considered regarding nutritional advice for infants with FPIES. (C) 2021 American Academy of Allergy, Asthma & Immunology
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INDUCED ENTEROCOLITIS SYNDROME; AMERICAN ACADEMY; COWS MILK; MANAGEMENT; ALLERGY; COMMITTEE; ASTHMA; FPIES; Children; Germany; Food protein-induced enterocolitis syndrome; Food allergy; Tolerance development; IgE; Triggering foods |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jan 2024 13:56 |
| Last Modified: | 29 Jan 2024 14:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58506 |
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