Weihrauch-Bluher, Susann and Wiegand, Susanna and Weihe, Paul and Prinz, Nicole and Weghuber, Daniel and Leipold, Georg and Dannemann, Almut and Bergjohann, Lara and Reinehr, Thomas and Holl, Reinhard W. (2023) Uric acid and gamma-glutamyl-transferase in children and adolescents with obesity: Association to anthropometric measures and cardiometabolic risk markers depending on pubertal stage, sex, degree of weight loss and type of patient care: Evaluation of the adiposity patient follow-up registry. PEDIATRIC OBESITY, 18 (3). ISSN 2047-6310, 2047-6302
Full text not available from this repository. (Request a copy)Abstract
Objectives Associations between body mass index (BMI)- standard deviation score (SDS)/waist-to-height ratio (WHtR) were studied with (i) serum uric acid (sUA)/gamma-glutamyl-transferase (GGT) and (ii) cardiometabolic risk markers in children with obesity, considering sex, pubertal development, and degree of weight loss/type of patient care. Methods 102 936 children from the Adiposity-Follow-up registry (APV; 47% boys) were included. Associations were analysed between sUA/GGT and anthropometrics, transaminases, lipids, fasting insulin (FI), homeostasis model assessment of insulin resistance (HOMA-IR), triglycerides to HDL-cholesterol (TG/HDL)-ratio. Follow-up analyses (3-24 months after baseline) considered a BMI-SDS reduction >= 0.2 (n = 11 096) or >= 0.5 (n = 3728). Partialized correlation analyses for sex and BMI-SDS were performed, taking pubertal development into consideration. Results At baseline, BMI-SDS showed the strongest correlations to sUA (r = 0.35; n = 26 529), HOMA-IR/FI (r = 0.30; n = 5513 /n = 5880), TG/HDL-ratio (r = 0.23; n = 24 501), and WHtR to sUA (r = 0.32; n = 10 805), GGT (r = 0.34; n = 11 862) and Alanine-aminotransferase (ALAT) (r = 0.33; n = 11 821), with stronger correlations in boys (WHtR and GGT: r = 0.36, n = 5793) and prepubertal children (r = 0.36; n = 2216). GGT and sUA (after partializing effects of age, sex, BMI-SDS) showed a correlation to TG/HDL-ratio (r = 0.27; n = 24 501). Following a BMI-SDS reduction >= 0.2 or >= 0.5, GGT was most strongly related to Aspartate-aminotransferase (ASAT)/ ALAT, most evident in prepuberty and with increasing weight loss, and also to TG/HDL-ratio (r = 0.22; n = 1528). Prepubertal children showed strongest correlations between BMI-SDS/WHtR and GGT. Delta BMI-SDS was strongly correlated to Delta sUA (r = 0.30; n = 4160) and Delta GGT (r = 0.28; n = 3562), and Delta WHtR to Delta GGT (r = 0.28; n = 3562) (all p < 0.0001). Conclusion Abdominal obesity may trigger hyperuricemia and hepatic involvement already in prepuberty. This may be stronger in infancy than anticipated to date. Even moderate weight loss has favourable effects on cardiometabolic risk profile and glucose homeostasis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IMPAIRED GLUCOSE-TOLERANCE; BODY-MASS INDEX; INSULIN-RESISTANCE; METABOLIC SYNDROME; BLOOD-PRESSURE; INTERVENTION; HYPERTENSION; PERCENTILES; OVERWEIGHT; COMPONENTS; APV registry; cardiometabolic risk markers; childhood obesity; pubertal development; serum uric acid; gamma-glutamyl-transferase |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Mar 2024 13:51 |
| Last Modified: | 05 Mar 2024 13:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58646 |
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