Hsam, Ohnmar and Kohl, Zacharias (2023) Serotonin in synucleinopathies. BEHAVIOURAL BRAIN RESEARCH, 445: 114367. ISSN 0166-4328, 1872-7549
Full text not available from this repository. (Request a copy)Abstract
Dysfunction of the serotonergic system represents an important feature in synucleinopathies like Parkinson disease (PD), dementia with Lewy bodies (DLB) and Multiple system atrophy (MSA). Serotonergic fibers from the raphe nuclei (RN) extend broadly throughout the central nervous system, innervating several brain areas affected in synucleinopathies. Alterations of the serotonergic system are associated with non-motor symptoms or motor complications in PD as well as with autonomic features of MSA. Postmortem studies, data from transgenic animal models and imaging techniques greatly contributed to the understanding of this serotonergic pathophysiology in the past, even leading to preclinical and clinical candidate drug tests targeting different parts of the serotonergic system. In this article, we review most recent work extending the knowledge of the serotonergic system and highlighting its relevance for the pathophysiology of synucleinopathies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MULTIPLE SYSTEM ATROPHY; PARKINSONS-DISEASE; PIMAVANSERIN TREATMENT; ALPHA-SYNUCLEIN; PATHOLOGY; DEMENTIA; IMPAIRMENT; DIAGNOSIS; SYMPTOMS; EFFICACY; Serotonin; Parkinson disease; Multiple system atrophy; Dementia with Lewy bodies; Serotonin transporter |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Jan 2024 09:06 |
| Last Modified: | 30 Jan 2024 09:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/58923 |
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