Hofmann, Evamaria and Saridis, Anna and Touraud, Didier and Buchner, Richard and Kunz, Werner (2023) In-depth study of binary ethanol-triacetin mixtures in relation to their excellent solubilization power. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 25 (30). pp. 20728-20736. ISSN 1463-9076, 1463-9084
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A significant synergistic effect is observed when solubilizing curcumin or tetrahydrocurcumin in binary mixtures of ethanol and triacetin. The present work deals with a detailed investigation of the solvent system by means of COSMO-RS-based calculations, dynamic light scattering, small-and-wide-angle X-ray scattering, and dielectric relaxation spectroscopy. Theoretical calculations lead to the conclusion that the enhanced solubility is not primarily the result of an interaction optimum between individual surface charge densities. Scattering experiments also exclude the formation of mesoscopic structures as the main reason. However, dielectric relaxation spectra suggest that in the concentration range of 0.3 & LE; x(triacetin) & LE; 0.6, ethanol molecules are released from their living polymer ethanol network and can interact with triacetin on a molecular level. The mesoscopic aggregation, thus, decreases. The concentration range of the ethanol-triacetin complexes has a significant overlap with the range of maximum solubility of (tetrahydro)curcumin. Nevertheless, despite detailed investigations, the exact origin of the solubilization power of the solvent remains speculative.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COSMO-RS; DIELECTRIC-RELAXATION; COPOLYMER; WATER |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 500 Science > 570 Life sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry VI - Physical Chemistry (Solution Chemistry) > Prof. Dr. Werner Kunz Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry VI - Physical Chemistry (Solution Chemistry) > PD Dr. Richard Buchner |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Feb 2024 07:26 |
| Last Modified: | 28 Feb 2024 07:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59161 |
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