Doppler, Michael and Fuernstahl, Christin and Hammer, Simone and Melter, Michael and Verloh, Niklas and Schlitt, Hans Juergen and Uller, Wibke (2023) Biliary Leak after Pediatric Liver Transplantation Treated by Percutaneous Transhepatic Biliary Drainage-A Case Series. TOMOGRAPHY, 9 (5). pp. 1965-1975. ISSN 2379-1381, 2379-139X
Full text not available from this repository. (Request a copy)Abstract
Background: Biliary leaks are a severe complication after pediatric liver transplantation (pLT), and successful management is challenging. Objectives: The aim of this case series was to assess the outcome of percutaneous transhepatic biliary drainage (PTBD) in children with bile leaks following pLT. The necessity of additional percutaneous bilioma drainage and laboratory changes during therapy and follow-up was documented. Material and Methods: All children who underwent PTBD for biliary leak following pLT were included in this consecutive retrospective single-center study and analyzed regarding site of leak, management of additional bilioma, treatment response, and patient and transplant survival. The courses of inflammation, cholestasis parameters, and liver enzymes were retrospectively reviewed. Results: Ten children underwent PTBD treatment for biliary leak after pLT. Seven patients presented with leakage at the hepaticojejunostomy, two with leakage at the choledocho-choledochostomy and one with a bile leak because of an overlooked segmental bile duct. In terms of the mean, the PTBD treatment started 40.3 +/- 31.7 days after pLT. The mean duration of PTBD treatment was 109.7 +/- 103.6 days. Additional percutaneous bilioma drainage was required in eight cases. Bile leak treatment was successful in all cases, and no complications occurred. The patient and transplant survival rate was 100%. CRP serum level, leukocyte count, gamma-glutamyl transferase (GGT), and total and direct bilirubin level decreased significantly during treatment with a very strong effect size. Additionally, the gamma-glutamyl transferase level showed a statistically significant reduction during follow-up. Conclusions: PTBD is a very successful strategy for bile leak therapy after pLT.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RISK-FACTORS; COMPLICATIONS; MANAGEMENT; DIAGNOSIS; LESIONS; PTBD; pediatric liver transplantation; biliary leak; pLTx; percutaneous transhepatic biliary drainage |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Kinder- und Jugendmedizin Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Mar 2024 13:36 |
| Last Modified: | 08 Mar 2024 13:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59163 |
Actions (login required)
 |
View Item |
