Neumann, Bernhard and Hierl, Andreas and Wunderlich, Silke and Meier, Helen and Bauer, Christina and Gerner, Stefan T. and Rieder, Georg and Geis, Tobias and Kunkel, Juergen and Bauswein, Markus and Niller, Hans Helmut and Schmidt, Barbara and Rubbensroth, Dennis and Beer, Martin and Linker, Ralf A. and Jantsch, Jonathan and Angstwurm, Klemens (2023) Cerebrospinal fluid in Borna disease virus 1 (BoDV-1) encephalitis. JOURNAL OF THE NEUROLOGICAL SCIENCES, 446: 120568. ISSN 0022-510X, 1878-5883
Full text not available from this repository. (Request a copy)Abstract
Borna disease virus 1 (BoDV-1) has been recognized as a rare cause of very severe encephalitis with rapid onset in central Europe. Data on cerebrospinal fluid (CSF) analysis have not yet been analyzed in detail. Here, we present the first study on CSF changes in BoDV-1 encephalitis. We retrospectively analyzed CSFs from 18 BoDV-1 encephalitis cases from Bavaria, Germany, an endemic region, from 1996 to 2021. Data were obtained through review of medical records and institutional databases. We found that white blood cell count (WBC) in CSF is elevated in 13 of our 18 patients at first examination (average 83.2 +/- 142.3 leukocytes/mu l) and cytology showed predominance of lymphocytes. Patients with typical symptoms of meningoencephalitis had higher WBC in first CSF analyzation (133.5 +/- 163.1 vs 4.0 +/- 3.2/mu l; p = 0.065). BoDV-1 PCR of CSF is not always positive when tested (7 of 9 cases). Four of five patients tested showed a polyvalent reaction against multiple viruses in the CSF suggesting that BoDV1 may trigger autoimmune mechanisms. CSF changes in BoDV-1 encephalitis seem similar to those of other viral encephalitis and at the beginning WBC can be normal in up to 28%, making the diagnosis even more challenging. All in all, BoDV-1 should be included in the diagnostic workup of patients with rapidly evolving and/or severe encephalitis and patients with severe neuropathy and secondary encephalopathy with and without CSF changes. Repeated CSF examinations as well as BoDV-1 serology and CSF PCR have to be considered in endemic areas.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; Cerebrospinal fluid; Borna disease virus 1 (BoDV-1); Viral encephalitis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Jan 2024 10:08 |
| Last Modified: | 30 Jan 2024 10:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59343 |
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