Weber, Daniela and Weber, Markus and Meedt, Elisabeth and Ghimire, Sakhila and Wolff, Daniel and Edinger, Matthias and Poeck, Hendrik and Hiergeist, Andreas and Gessner, Andre and Ayuk, Francis and Roesler, Wolf and Woel, Matthias and Kraus, Sabrina and Zeiser, Robert and Bertrand, Hannah and Bader, Peter and Ullrich, Evelyn and Eder, Matthias and Gleich, Sigrun and Young, Rachel and Herr, Wolfgang and Levine, John E. and Ferrara, James L. M. and Holler, Ernst (2023) Reg3? concentrations at day of allogeneic stem cell transplantation predict outcome and correlate with early antibiotic use. BLOOD ADVANCES, 7 (7). pp. 1326-1335. ISSN 2473-9529, 2473-9537
Full text not available from this repository. (Request a copy)Abstract
Intestinal microbiome diversity plays an important role in the pathophysiology of acute gastrointestinal (GI) graft-versus-host disease (GVHD) and influences the outcome of patients after allogeneic stem cell transplantation (ASCT). We analyzed clinical data and blood samples taken preconditioning and on the day of ASCT from 587 patients from 7 German centers of the Mount Sinai Acute GVHD International Consortium, dividing them into single-center test (n = 371) and multicenter validation (n = 216) cohorts. Regenerating islet-derived 3 alpha (Reg3 alpha) serum concentration of day 0 correlated with clinical data as well as urinary 3-indoxylsulfate (3-IS) and Clostridiales group XIVa, indicators of intestinal microbiome diversity. High Reg3 alpha concentration at day 0 of ASCT was associated with higher 1-year transplant-related mortality (TRM) in both cohorts (P < .001). Cox regression analysis revealed high Reg3 alpha at day 0 as an independent prognostic factor for 1-year TRM. Multivariable analysis showed an independent correlation of high Reg3 alpha concentrations at day 0 with early systemic antibiotic (AB) treatment. Urinary 3-IS (P = .04) and Clostridiales group XIVa (P = .004) were lower in patients with high vs those with low day 0 Reg3 alpha concentrations. In contrast, Reg3 alpha concentrations before conditioning therapy correlated neither with TRM nor disease or treatment-related parameters. Reg3 alpha, a known biomarker of acute GI GVHD correlates with intestinal dysbiosis, induced by early AB treatment in the period of pretransplant conditioning. Serum concentrations of Reg3 alpha measured on the day of graft infusion are predictive of the risk for TRM of ASCT recipients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEUTROPENIC PATIENTS; ALPHA-DEFENSINS; PANETH CELLS; MICROBIOTA; RISK; DIVERSITY; BIOMARKER; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Zentren des Universitätsklinikums Regensburg > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Jan 2024 11:21 |
| Last Modified: | 30 Jan 2024 11:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59741 |
Actions (login required)
 |
View Item |
