Taheri, Shadi and Peters, Nils and Zietz, Annaelle and Abel, Berthold and Hubert, Gordian and Barinka, Filip and Wiestler, Hanni and Kovacic, Irena and Linker, Ralf and Schlachetzki, Felix and Backhaus, Roland (2023) Clinical Course and Recurrence in Transient Global Amnesia: A Study From the TEMPiS Telestroke Network. JOURNAL OF CLINICAL NEUROLOGY, 19 (6). pp. 530-538. ISSN 1738-6586, 2005-5013
Full text not available from this repository. (Request a copy)Abstract
Background and Purpose While the clinical hallmarks of transient global amnesia (TGA) are well defined, its pathophysiological causes are poorly understood. Specifically, risk factors for recurrences are yet to be determined.Methods This retrospective study analyzed TGA cases diagnosed and treated within the TEMPiS telestroke network and a university stroke center in Germany. Demographic and clinical data were assessed and characteristics of TGA episodes were recorded, such as season of occurrence, trigger factors, duration, and concomitant symptoms. Follow-up of the potential recurrence of TGA was performed using a standardized questionnaire.Results Overall 109 patients were included (age 64 +/- 8 years [mean +/- SD], 59.6% female). The most common vascular risk factor was arterial hypertension (60.6%), and other concomitant conditions included migraine (11.9%), hypothyroidism (22.9%), and atrial fibrillation (4.6%). The most frequent concomitant clinical feature accompanying the TGA episode at admission was elevated blood pressure (48.6%). Nineteen patients experienced at least one recurrent TGA episode. Migraine and hypothyroidism were only observed in subjects with a single TGA episode without recurrence (migraine: 14.4% without recurrence vs. none in the recurrence group, p=0.02; hypothyroidism: 27.8% without recurrence vs. none in the recurrence group, p=0.009). In contrast, atrial fibrillation was more common in subjects with TGA recurrence (p<0.001).Conclusions Arterial hypertension is prevalent in TGA patients, with elevated blood pressure being the most-frequent concomitant condition. In our cohort, recurrence of TGA occurred in approximately one-fifth of patients. Concomitant conditions such as migraine, hypothyroidism, and atrial fibrillation occurred at different frequencies in the two groups.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RISK-FACTORS; NATURAL-HISTORY; STROKE CARE; THROMBOLYSIS; FEATURES; PROJECT; ANATOMY; transient global amnesia; arterial hypertension; recurrent TGA; trigger factors; telemedical stroke network |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Mar 2024 11:33 |
| Last Modified: | 16 Mar 2024 11:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60148 |
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