Harder, Inken and Stoelzl, Dora and Sander, Nicole and Hartmann, Jan and Rodriguez, Elke and Mazur, Carsten and Kerzel, Sebastian and Kabesch, Michael and Kuester, Denise and Schmitt, Jochen and Foelster-Holst, Regina and Gerdes, Sascha and Emmert, Hila and Weidinger, Stephan (2023) Effects of Early Emollient Use in Children at High Risk of Atopic Dermatitis: A German Pilot Study. ACTA DERMATO-VENEREOLOGICA, 103. ISSN 0001-5555, 1651-2057
Full text not available from this repository. (Request a copy)Abstract
Several small studies have indicated that daily emollient use from birth might delay, suppress or prevent atopic dermatitis (AD). Two larger trials did not confirm this; however, a recent smaller study indicated a protective effect if daily emollient use is used in the first 2 months of life. Further research is needed to evaluate the effect of emollient use on development of AD. The current study randomly assigned 50 newborns who were at high risk of developing AD (1:1) to receive general infant skin-care advice (control group), or skin-care advice plus emollient with advice to apply emollient at least once daily until 1 year of age (intervention group). Repeated skin examinations, skin physiology measurements and skin microbiome profiling were performed. Of the children in the intervention and control groups, 28% and 24%, respectively, developed AD (adjusted Relative Risk (RR) 1.19, p = 0.65, adjusted risk difference 0.05). Skin pH decreased and transepidermal water loss and stratum corneum hydration increased over time in both groups with no significant differences. In the intervention group skin microbiome alpha diversity increased earlier, and the abundance of Streptococcus and Staphylococcus species were significantly reduced at month 1. Daily early emollient use in children with high risk of AD was safe, but it did not significantly reduce the risk of developing AD or impact skin physiology development.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PARTY DIAGNOSTIC-CRITERIA; SKIN; ECZEMA; atopic dermatitis; early emollient; skin barrier; skin physiology |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Mar 2024 14:59 |
| Last Modified: | 19 Mar 2024 14:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60371 |
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