Barna, Andras Jozsef and Herold, Zoltan and Acs, Miklos and Bazsa, Sandor and Gajdacsi, Jozsef and Garay, Tamas Marton and Herold, Magdolna and Madaras, Lilla and Muhl, Dorottya and Nagy, Akos and Szasz, Attila Marcell and Dank, Magdolna (2023) High Tumor-Infiltrating Lymphocyte Count Is Associated with Distinct Gene Expression Profile and Longer Patient Survival in Advanced Ovarian Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (18): 13684. ISSN 1661-6596, 1422-0067
Full text not available from this repository. (Request a copy)Abstract
Cancer-related immunity plays a significant role in the outcome of ovarian cancer, but the exact mechanisms are not fully explored. A retrospective, real-life observational study was conducted including 57 advanced ovarian cancer patients. Immunohistochemistry for CD4+, CD8+, and CD45+ was used for assessing tumor-infiltrating immune cells. Furthermore, an immune-related gene expression assay was performed on 12-10 samples from patients with less than and more than 1-year overall survival (OS), respectively. A higher number of CD4+ (p = 0.0028) and CD45+ (p = 0.0221) immune cells within the tumor microenvironment were associated with longer OS of patients. In a multivariate setting, higher CD4+ T cell infiltration predicted longer OS (p = 0.0392). Twenty-three differentially expressed genes-involved in antigen presentation, costimulatory signaling, matrix remodeling, metastasis formation, and myeloid cell activity-were found when comparing the prognostic groups. It was found that tumor-infiltrating immune cell counts are associated with peculiar gene expression patterns and bear prognostic information in ovarian cancer. SOX11 expression emerged and was validated as a predictive marker for OS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTRATUMORAL T-CELLS; RNA-SEQ DATA; FAVORABLE PROGNOSIS; MICROENVIRONMENT; RECURRENCE; CARCINOMA; REVEAL; ovarian neoplasms; immunohistochemistry; NanoString; CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; CD45-positive leukocytes; leukocyte common antigens |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Mar 2024 07:00 |
| Last Modified: | 26 Mar 2024 07:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60546 |
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