Heinrich, Maria A. and Stark, Klaus J. and Zimmermann, Martina E. and Herold, Janina M. and Brandl, Caroline and Schober, Alexander D. and Burkhardt, Ralph and Maier, Lars S. and Luchner, Andreas and Heid, Iris M. and Dietl, Alexander (2025) NT-proBNP in the very old population: reference values and heart failure specificity from the AugUR-study. SPRINGER HEIDELBERG, HEIDELBERG.
Full text not available from this repository. (Request a copy)Abstract
BackgroundHigh NT-proBNP is an established marker of heart failure. However, old individuals have elevated values even when cardiovascularly healthy. Reference values remain scarce.ObjectivesWe sought to provide reference values of NT-proBNP for the healthy old and very old population and the proportion above the AHA- and ESC-recommended rule-out cut-off for heart failure diagnosis in a non-acute setting (>= 125 pg/mL).MethodsWe analyzed cross-sectional data from the population-based AugUR study of inhabitants >= 70 years of age. NT-proBNP was determined in serum. Cardiac morphology and function were evaluated by echocardiography.ResultsA total of 2304 subjects aged 70 to 95 years were analyzed (52% women; 35% >= 80 years). Median NT-proBNP increased by age group (70-74/75-79/80-84/ >= 85 years: 153.0/176.9/228.5/395.0 and 116.1/171.5/217.6/437.0 pg/mL for women or men, respectively); 68% had NT-proBNP >= 125 pg/mL. In a subgroup free of cardiovascular risk factors, renal failure, coronary artery disease, and atrial fibrillation (n = 685), 50% (70-79 years) and 70% (>= 80 years) had NT-proBNP >= 125 pg/mL; 97.5% quantiles were considerably higher than 125 pg/mL (70-79 years: 559.5 or 424.5 for women or men; 80-95 years: 809.2 or 722.0 pg/mL for women or men). When further restricting to normal left ventricular mass, E/e ' ratio, and ejection fraction (n = 65), 53% of subjects (70-79 years) or 50% (>= 80 years) had NT-proBNP >= 125 pg/mL.ConclusionsNT-proBNP levels continue to rise in the very old population. More than 50% of healthy subjects aged 70 years and older have NT-proBNP values above the decision-making cut-off at 125 pg/mL, potentially causing unnecessary further diagnostics and referrals.
| Item Type: | Other |
|---|---|
| Uncontrolled Keywords: | BRAIN NATRIURETIC PEPTIDE; EUROPEAN ASSOCIATION; AMERICAN SOCIETY; AGE; ECHOCARDIOGRAPHY; RECOMMENDATIONS; DETERMINANTS; UPDATE; MARKER; IMPACT; NT-proBNP; Elderly; Population-based; Specificity; Reference value |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 May 2026 07:16 |
| Last Modified: | 12 May 2026 07:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65798 |
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