Haedenkamp, Tareq M. and Goetz, Lindg and Ansafi, Tananeh and Gerken, Michael and Klinkhammer-Schalke, Monika and Fischl, Anna and Riemenschneider, Markus J. and Maurer, Julia and Proescholdt, Martin and Koelbl, Oliver and Schmidt, Nils Ole and Linker, Ralf and Bumes, Elisabeth and Hau, Peter (2025) Dietary habits in relation to outcome and therapy-related toxicity in patients with glioblastoma - a retrospective cohort study. JOURNAL OF NEURO-ONCOLOGY, 175 (1). pp. 345-355. ISSN 0167-594X, 1573-7373
Full text not available from this repository. (Request a copy)Abstract
Purpose Glioblastoma is the most prevalent primary malignant brain tumour in adults and bears poor survival. Data on associations of nutrition with outcome parameters are scarce. Our aim was to investigate whether dietary habits influence chemotherapy-related toxicity and overall survival in patients with glioblastoma. Methods In this retrospective cohort study, we included glioblastoma patients who received treatment between January 2010 and December 2019. We used a 35-item food frequency questionnaire to calculate a dietary score based on Mediterranean-like diet recommendations. We analysed relationships between nutrition score, side effects and survival using chi square tests, binary logistic regression, Kaplan-Meier and multivariable Cox regression analyses. Results From an initial population of 1,448 patients, a homogenous cohort of 128 glioblastoma cases were included in our final analysis. Patients with a higher score than the median, tending to a more Mediterranean-like diet, showed more infections (13.8% vs. 3.2%, p = 0.031) and a trend for more myelodepression (32.3% vs. 17.5%, p = 0.052). A higher score was predictive for infections (OR = 12.33, 95% CI: 1.36-111.98; p = 0.026). Median survival was worse in the higher score group (16.6 vs. 19.4 months, p = 0.004), confirmed by multivariable cox regression analysis (HR 1.60, 95% CI 1.04-2.46; p = 0.034). Conclusion We identified associations between dietary patterns and chemotherapy-related toxicity as well as outcome. Our findings underscore the potential impact of nutrition on cancer treatment outcomes. Further research is needed to validate these results and to address possible underlying mechanisms.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TEMOZOLOMIDE; GLIOMA; CONSUMPTION; MORTALITY; PROTEIN; RISK; Glioblastoma; Diet; Food frequency questionnaire; Therapy-related toxicity; Survival |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie Medicine > Lehrstuhl für Neurologie Medicine > Abteilung für Neuropathologie Medicine > Lehrstuhl für Strahlentherapie Medicine > Zentren des Universitätsklinikums Regensburg > Tumorzentrum e.V. |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 May 2026 05:47 |
| Last Modified: | 19 May 2026 05:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65812 |
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