Inhaled nebulised medications in palliative care - a survey among palliative care practitioners in Germany

Mair, Ruth and Schnell, Annette and Steger-Arand, Christine and Herr, Wolfgang and Rechenmacher, Michael (2025) Inhaled nebulised medications in palliative care - a survey among palliative care practitioners in Germany. BMC PALLIATIVE CARE, 24 (1): 125. ISSN 1472-684X,

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Abstract

BackgroundIn palliative care, alternative routes for drug application besides the oral and intravenous administration are frequently necessary. Up-to-date, very little is known about the familiarity, use and perceived relevance of inhalative medications for symptom control among palliative care practitioners.MethodsWe conducted an anonymous online survey among palliative care physicians throughout Germany between 09/2021 and 04/2022. The questionnaire covered participants' sociodemographics, as well as familiarity, perceived relevance and prescription practices regarding 21 nebulised drugs. Analysis was performed using methods of descriptive statistics.Results108 fully completed questionnaires were analysed. Most of the participants were employed in palliative care for 5 + years. The administration of normal saline, mucoactive drugs, bronchodilators and steroids via nebulisation was a widely known and frequently used technique among the participants, as evidenced by its regular use in clinical routine. About 50% of the participants reported to know epinephrine and tranexamic acid for anti-oedematous or haemostyptic effects, respectively. Both drugs were considered "relevant" by more than 60% of the prescribers. Only a minority of participants reported to know and use nebulised opioids, iloprost, several antibiotics, heparin, ketamine and lidocaine.ConclusionsOur survey shows that nebulised drugs are prescribed and considered relevant in palliative care. However, for several of the mentioned medications only limited data is available regarding use and effectivity. There is also uncertainty to what extent the existing data may be transferable into routine palliative care setting. Therefore, more evidence should be generated.Trial registrationNot applicable.

Item Type: Article
Uncontrolled Keywords: TRANEXAMIC ACID; MUCOACTIVE AGENTS; CANCER-PATIENTS; FENTANYL; DYSPNEA; ADRENALINE; LIDOCAINE; HEPARIN; RELIEF; PILOT; Palliative care; Inhalation; Inhalative; Nebulisation; Nebulised; Symptom control
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Depositing User: Dr. Gernot Deinzer
Date Deposited: 26 Aug 2026 07:57
Last Modified: 26 Aug 2026 07:57
URI: https://pred.uni-regensburg.de/id/eprint/65820

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