Schmidleithner, Lisa and Stueve, Philipp and Feuerer, Markus (2025) Transposable elements as instructors of the immune system. NATURE PORTFOLIO, BERLIN.
Full text not available from this repository. (Request a copy)Abstract
Transposable elements (TEs) are mobile repetitive nucleic acid sequences that have been incorporated into the genome through spontaneous integration, accounting for almost 50% of human DNA. Even though most TEs are no longer mobile today, studies have demonstrated that they have important roles in different biological processes, such as ageing, embryonic development, and cancer. TEs influence these processes through various mechanisms, including active transposition of TEs contributing to ongoing evolution, transposon transcription generating RNA or protein, and by influencing gene regulation as enhancers. However, how TEs interact with the immune system remains a largely unexplored field. In this Perspective, we describe how TEs might influence different aspects of the immune system, such as innate immune responses, T cell activation and differentiation, and tissue adaptation. Furthermore, TEs can serve as a source of neoantigens for T cells in antitumour immunity. We suggest that TE biology is an important emerging field of immunology and discuss the potential to harness the TE network therapeutically, for example, to improve immunotherapies for cancer and autoimmune and inflammatory diseases.
| Item Type: | Other |
|---|---|
| Uncontrolled Keywords: | EMBRYONIC STEM-CELLS; DNA-METHYLATION; ENDOGENOUS RETROVIRUSES; L1 RETROTRANSPOSITION; SOMATIC RETROTRANSPOSITION; TRANSCRIPTION FACTOR; EVOLUTION; GENOME; GENE; CANCER; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 May 2026 08:21 |
| Last Modified: | 19 May 2026 08:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65824 |
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