Kupke, Paul and Kupke, Laura S. and Glehr, Gunther and Evert, Katja and Einspieler, Ingo and Hornung, Matthias and Stroszczynski, Christian and Geissler, Edward K. and Schlitt, Hans J. and Hutchinson, James A. and Werner, Jens M. (2025) Soluble CD46 improves detection of hepatic steatosis by contrast-enhanced computed tomography before liver surgery. INTERNATIONAL JOURNAL OF SURGERY, 111 (6). pp. 4086-4089. ISSN 1743-9191, 1743-9159
Full text not available from this repository. (Request a copy)Abstract
Soluble CD46 (sCD46) has recently been shown to be an effective biomarker of steatotic liver disease (SLD), which is highly prevalent in the western world. Since SLD directly affects outcomes after major hepatectomies and liver transplantation, accurate appraisal of this condition is crucial before liver surgery. In the present study, we asked whether sCD46 measurement in patient plasma could augment the pre-surgical prediction of SLD performed by contrast-enhanced computed tomography. Our data show that combined performance of these tests reveals an area under the curve for the prediction of high-grade SLD of 0.956. After cross-validation, our clinical score leads to an accuracy of 95.12% to detect severe steatosis. Therefore, sCD46 is a promising biomarker for optimizing pre-surgical decision-making assessments, with the aim to identify patients that could benefit from alternative treatment options.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CT; contrast-enhanced computed tomography; preoperative imaging; soluble CD46; steatotic liver disease; surgery complications |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 May 2026 06:57 |
| Last Modified: | 26 May 2026 06:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65860 |
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