Abken, Hinrich (2025) CAR T cell therapies in gastrointestinal cancers: current clinical trials and strategies to overcome challenges. NATURE PORTFOLIO, BERLIN.
Full text not available from this repository. (Request a copy)Abstract
Despite multimodal treatment options, most gastrointestinal cancers are still associated with high mortality rates and poor responsiveness to immunotherapy. The unprecedented efficacy of chimeric antigen receptor (CAR)-engineered T cells in the treatment of haematological malignancies raised interest in translating CAR T cell therapies to the treatment of gastrointestinal cancers. Treatment of solid cancers with canonical CAR T cells faces substantial challenges, including the dense architecture of the tumour tissue, the tolerogenic environment with low tumour-intrinsic immunogenicity, the rareness of targetable tumour-selective antigens, the antigenic heterogeneity of cancer cells, and the profound metabolic and immune cell disbalances. This Review provides an overview of CAR T cell trials in the treatment of gastrointestinal cancers, discussing considerations relating to safety, efficacy, potential reasons for failure and options for improving CAR T cells for the future. In addition, lessons regarding how to improve efficacy are drawn from CAR T cells armed with adjuvants that sustain their activation within the hostile environment and activate resident immune cells. As the field is rapidly evolving, current treatment modalities and editing CAR T cell functionalities are being refined towards a potentially more successful CAR T cell therapy for gastrointestinal cancers.
| Item Type: | Other |
|---|---|
| Uncontrolled Keywords: | CHIMERIC ANTIGEN RECEPTORS; TARGETING SOLID TUMORS; PHASE-I; CARCINOEMBRYONIC ANTIGEN; ANTITUMOR-ACTIVITY; MESOTHELIN; IMMUNOTHERAPY; EXPRESSION; EFFICACY; RECOGNITION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 May 2026 09:08 |
| Last Modified: | 26 May 2026 09:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65871 |
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