Zerdzitzki, Matthaeus and Pfister, Karin and Schierling, Wilma and Zeman, Florian and Toepel, Ingolf and Steinbauer, Markus and Betz, Thomas (2025) Outcomes of biosynthetic collagen prostheses with comparison to cryopreserved arterial homografts for bypass reconstruction in infrainguinal vascular graft infections. SCANDINAVIAN JOURNAL OF SURGERY, 114 (2). pp. 248-257. ISSN 1457-4969, 1799-7267
Full text not available from this repository. (Request a copy)Abstract
Background and Aims: Managing infrainguinal vascular graft infections (VGI) in bypass reconstruction is complex. Although an autologous vein is the preferred graft material, alternative conduits are required when autologous veins are unavailable. This study aimed to compare the efficacy of cryopreserved arterial homografts and biosynthetic glutaraldehydemodifiedovine collagen grafts (Omniflow II) for the treatment of infrainguinal VGI.Methods: The study was retrospective across two centers and included patients with infrainguinal VGI treated with cryopreserved arterial homografts or Omniflow II grafts between 2009 and 2019. Freedom from reinfection, primary patency rates, amputation-free survival, and overall survival were analyzed using 5-year Kaplan-Meier estimates.Results: Overall, 63 patients with infrainguinal VGI were treated with either Omniflow II grafts (n = 34) or cryopreserved arterial homografts (n = 29). At 5 years, freedom from reinfection was 97.1% for Omniflow II grafts and 93.1% for cryopreserved arterial homografts (p = .4). Primary patency was 50% for Omniflow II grafts and 55.2% for the cryopreserved arterial homografts (p = .5). Amputation-free survival was 52.9% for Omniflow II grafts and 55.2% for cryopreserved arterial homografts (p = .7). No graft degeneration or graft ruptures were observed during the follow-up.Conclusions: This study suggests that biosynthetic grafts are viable and accessible alternatives for traditional graft materials, offering similar efficacy and ease of use. Although autologous vein grafts remain the gold standard for VGI management, biosynthetic grafts may serve as a viable alternatives to cryopreserved arterial homografts in the treatment of infrainguinal VGIs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OMNIFLOW II; REVASCULARIZATION; EXPERIENCE; VEIN; Vascular graft infections; long-term follow-up; lower limb; biosynthetic collagen prostheses; cryopreserved human vascular grafts |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Gefäßchirurgie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Jun 2026 09:28 |
| Last Modified: | 09 Jun 2026 09:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65944 |
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