Bayram, Fatma and Hegner, Philipp and Lauerer, Anna-Maria and Schildt, Soenke and Wermers, Dominik and Baier, Maria Johanna and Mustroph, Julian and Tafelmeier, Maria and Provaznik, Zdenek and Schmid, Christof and Maier, Lars Siegfried and Wagner, Stefan and Arzt, Michael and Lebek, Simon (2025) Myocardial DYRK1B Expression Is Increased in Patients with Impaired Cardiac Contractility and Sleep-Disordered Breathing. ANTIOXIDANTS, 14 (2): 163. ISSN , 2076-3921
Full text not available from this repository. (Request a copy)Abstract
Heart failure and cardiovascular disease represent a significant burden on healthcare systems worldwide. Recent evidence associates an increased expression of the dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B) with an impaired cardiac function in mice. However, there remains a paucity of data on myocardial DYRK1B expression in patients with cardiovascular disease in the context of other comorbidities. In our study, we examined DYRK1B mRNA expression in human right atrial appendage biopsies from 159 patients undergoing elective coronary artery bypass surgery. Each patient was tested for sleep-disordered breathing the night prior to surgery. In this large representative study cohort with cardiovascular high-risk patients, we found that an impaired cardiac function as well as sleep-disordered breathing (SDB), including various oxidative stress parameters, were associated with an increased myocardial DYRK1B expression. A multivariate regression analysis revealed left ventricular ejection fraction and the presence of SDB as significant predictors of the myocardial DYRK1B expression independent of other clinical covariates. Based on these findings, DYRK1B represents a promising molecular target in patients with heart failure and reduced ejection fraction as well in patients with sleep-disordered breathing.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POSITIVE AIRWAY PRESSURE; CARDIOVASCULAR-DISEASES; MEDICATION ADHERENCE; APNEA; PROTEIN; EMPAGLIFLOZIN; MORTALITY; OUTCOMES; THERAPY; OBESITY; DYRK1B; heart failure; sleep-disordered breathing; cardiovascular disease; hypoxia |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Jun 2026 04:45 |
| Last Modified: | 23 Jun 2026 04:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65966 |
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