Babawale, Florenc and Ghosh, Indrajit and Koenig, Burkhard (2025) Photo-Catalyzed Synthesis of Indanones from Aromatic Aldehydes and Terminal Alkynes. JOURNAL OF ORGANIC CHEMISTRY, 90 (39). pp. 13885-13890. ISSN 0022-3263, 1520-6904
Full text not available from this repository. (Request a copy)Abstract
Indanones are key structural motifs in pharmaceuticals and bioactive natural products, making their efficient synthesis a subject of continued interest. Conventional methods typically rely on transition-metal catalysis, prefunctionalized substrates, and multiple redox steps. Herein, we report a photochemical C-H annulation strategy for the direct synthesis of indanones from simple, unmodified aromatic aldehydes and terminal alkynes. The reaction proceeds under 365 nm light using tetrabutylphosphonium decatungstate ([Bu4P]4W10O32, TBPDT) as a hydrogen atom transfer (HAT) photocatalyst. This prefunctionalization-free protocol tolerates a broad range of substrates, eliminates the need for additional redox steps, and expands the toolbox for sustainable indanone synthesis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARBONYLATIVE CYCLIZATION REACTIONS; O-IODOPHENYL KETONES; C-H; REGIOSELECTIVE CARBOCYCLIZATION; ANNULATION; INDENONES; CARBOPALLADATION; PHOTOCATALYSIS; DEUTERATION; ROUTE; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Jun 2026 08:06 |
| Last Modified: | 16 Jun 2026 08:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/65982 |
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