Schnobrich, Luisa and Castrop, Hayo (2025) Urinary microvesicles: a window into the kidney. OXFORD UNIV PRESS, OXFORD.
Full text not available from this repository. (Request a copy)Abstract
Chronic kidney disease (CKD) is a growing concern in aging populations. CKD is characterized by two hallmark symptoms: a decline in the glomerular filtration rate (GFR) and albuminuria. Early changes in kidney function are notoriously underdiagnosed, suggesting the need for new noninvasive diagnostic and prognostic biomarkers of CKD. Thus, analysis of urinary extracellular vesicles (uEVs) may broaden the diagnostic options for CKD. EVs are a heterogeneous group of particles, enclosed by a lipid bilayer, which differ in size, biogenesis, and function. EVs can be readily recovered from the urine (urinary EVs, uEVs), where they are derived from various cells of the kidney, bladder, prostate, and utero-vaginal tract. Within the kidney, EVs are released by almost all cell types, including but not limited to podocytes, cells of the proximal and distal tubules, the collecting duct, and the loop of Henle. In addition to specific markers of parental cells, uEVs carry mRNAs, miRNAs, and proteins. Thus, analysis of uEVs may provide insights into the content and composition of the specific cells from which they are released, leading to the identification of new diagnostic and prognostic biomarkers for kidney diseases of different etiologies. This review provides an overview of kidney disease-related changes in uEV size and concentration and covers the potential of uEVs as new biomarkers for various types of kidney disease. 10.1093/ckj/sfaf189 Video Abstract Watch the video abstract of this contribution sfaf189Media1 6375679659112
| Item Type: | Other |
|---|---|
| Uncontrolled Keywords: | TAMM-HORSFALL PROTEIN; EXTRACELLULAR VESICLES; EXOSOMES; BIOMARKERS; CIRCRNAS; DAMAGE; CELLS; biomarkers; diagnosis; kidney disease; prognosis; urinary extracellular vesicles |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Wolf Hayo Castrop |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jul 2026 07:09 |
| Last Modified: | 28 Jul 2026 07:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/66046 |
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