Birringer, Jan and Konrad, Johannes and Melchner, Stephan and Remmert, Marius and Goepferich, Achim (2025) Coumarin-Caged Nanoparticle for Light-Driven Surface Modification. CHEMMEDCHEM, 20 (22). ISSN 1860-7179, 1860-7187
Full text not available from this repository. (Request a copy)Abstract
Photo-labile protecting groups (PPG) allow for the selective activation of an originally caged moiety by light exposure at a specific wavelength. Incorporation of PPG in nanoparticles (NPs) enables precise spatiotemporal control over NPs surface properties. Thus, physicochemical and biological properties of NPs can be modified even after administration in a biological environment. In this study, this mechanism is used to control the cell uptake of NPs. To this end, polymeric core-shell NPs are used composed of poly(D, L-lactide-co-glycolide) and a poly(ethylene glycol)-b-poly(D, L-lactide) block copolymer, modified with positively charged cell-penetrating peptide (CPP). Surface charge of CPP-NPs (+23.50 mV), measured as zetapotential, is effectively diminished by the attachment of coumarin-derived PPG to CPP (+12.50 mV), resulting in reduced cell uptake. Upon light irradiation with light-emitting diode (lambda = 365 nm) the PPG is cleaved, restoring the zetapotential (+24.67 mV) and triggering an enhanced cell uptake. This opens the door to trigger the cellular uptake of NPs that are intended to transport drugs to their target cells in the future.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POLYMERIC MICELLE; RELEASE; PACLITAXEL; STABILITY; cell-penetrating peptides; charge-mediated uptake; nanoparticles; stimuli-responsive; surface chemistry |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 May 2026 05:01 |
| Last Modified: | 07 May 2026 05:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/66064 |
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