Koertl, Thomas and Muehleck, Franziska and Baum, Paul and Resch, Markus and Meindl, Christine and Uecer, Ekrem and Maier, Lars S. and Wachter, Rolf and Sossalla, Samuel and Schach, Christian (2025) Right Ventricular Systolic Dysfunction Predicts Recovery of Left Ventricular Systolic Function and Reduced Quality of Life in Patients With Arrhythmia-Induced Cardiomyopathy. CLINICAL CARDIOLOGY, 48 (2): e70070. ISSN 0160-9289, 1932-8737
Full text not available from this repository. (Request a copy)Abstract
IntroductionArrhythmia-induced cardiomyopathy (AIC) is an underrecognized condition resulting in left ventricular systolic dysfunction (LVSD) that is primarily caused by atrial fibrillation (AFib). The relationship between AIC, right ventricular (RV) function, and quality of life (QoL) has not been well studied.MethodsWe performed a post-hoc analysis of our AIC trial in which we prospectively screened for patients with tachyarrhythmia and newly diagnosed, otherwise unexplained LVSD. Following rhythm restoration, patients were followed up at 2, 4, and 6 months. Only patients with persistent sinus rhythm were analyzed. RV function was assessed via echocardiography (tricuspid annular plane systolic excursion [TASPE] and fractional area change [FAC]) and QoL by the Minnesota Living with Heart Failure Questionnaire.ResultsOf a total of 50 patients recovering from LVSD, 41 were diagnosed with AIC and 9 with non-AIC. Initially, RV function was reduced in the AIC group and recovered after rhythm restoration, whereas no relevant changes were noted in the non-AIC group. QoL was reduced in both groups and also improved after rhythm restoration. Regression analysis identified low TAPSE as a predictive parameter for AIC diagnosis and worse QoL in AIC patients.ConclusionWe demonstrated that RV function and QoL are impaired in patients with AIC. Six months after rhythm restoration, TAPSE may serve as an early indicator of AIC while also correlating with QoL. This underscores the importance of detailed echocardiographic evaluation with a focus on RV function in patients with concomitant tachyarrhythmia and LVSD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EUROPEAN ASSOCIATION; AMERICAN SOCIETY; HEART-FAILURE; ECHOCARDIOGRAPHY; ADULTS; STRAIN; arrhythmia-induced cardiomyopathy; atrial fibrillation; quality of life; right ventricular function |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Universitäres Herzzentrum Regensburg (UHR) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Sep 2026 07:57 |
| Last Modified: | 23 Sep 2026 07:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/66203 |
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