Mester, Patricia and Utrata, Alexander and Schmidtner, Niklas and Birner, Charlotte and Schmid, Stephan and Mueller, Martina and Pavel, Vlad and Buechler, Christa (2025) Lower Plasma IL-32 Levels Linked to Better Survival in Sepsis. BIOMEDICINES, 13 (3): 750. ISSN 2227-9059
Full text not available from this repository.Abstract
Background/Objectives: Interleukin-32 (IL-32) is a pro-inflammatory cytokine primarily produced by immune cells and involved in bacterial and viral infections. This study investigates whether plasma IL-32 is associated with sepsis severity and clinical outcomes. Methods: Plasma IL-32 levels were measured in 186 patients with systemic inflammatory response syndrome (SIRS), sepsis, or septic shock, as well as in 40 controls. The relationship between IL-32 levels and SARS-CoV-2 or bacterial infections, alongside underlying etiological conditions, was assessed. Results: Patients with liver cirrhosis exhibited elevated plasma IL-32 levels. After excluding these patients, IL-32 levels were lower in SIRS/sepsis patients compared to the controls. No significant differences in IL-32 levels were observed among SIRS, sepsis, and septic shock patients. Additionally, underlying conditions such as pancreatitis and cholangitis did not influence IL-32 levels. Patients with bloodstream bacterial infections, SARS-CoV-2 infections, or no documented infection had comparable IL-32 levels. Notably, higher IL-32 levels were associated with increased mortality. Conclusions: These findings suggest that a reduction in plasma IL-32 levels may be protective in SIRS/sepsis patients, as elevated levels are linked to poor survival outcomes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTERLEUKIN 32; INFLAMMATION; ACTIVATION; EXPRESSION; CELLS; COVID-19; liver cirrhosis; sepsis; mortality |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Sep 2026 05:35 |
| Last Modified: | 23 Sep 2026 05:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/66219 |
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