Hopmann, Lara and Heider, Judith and Niebel, Dennis and Evert, Katja and Zeman, Florian and Hammers, Christoph M. and Ettl, Tobias and Brochhausen, Christoph and Schreml, Stephan (2025) pH-Sensitive TRPC5 Is Differentially Expressed in Various Common Skin Tumors. BIOLOGY-BASEL, 14 (7): 823. ISSN 2079-7737
Full text not available from this repository. (Request a copy)Abstract
Transient receptor potential classical or cation channels (TRPCs) are integral to tumor biology, particularly in maintaining Ca2+ homeostasis within cancer cells. TRPC5, a pH-sensitive member of this family, may act as a signaling molecule in the altered microenvironment of solid tumors, which are characterized by an inverted pH-gradient-with decreased extracellular and increased intracellular pH-that promotes tumor progression. This study addresses a gap in the field, as there is currently limited research on TRPC5, particularly regarding its potential role as a tumor marker. While TRPCs are known to be involved in cancer biology, the specific role of TRPC5 in solid tumors, including its potential role as a diagnostic marker, remains largely unexplored. This study is the first to examine TRPC5 expression profiles in common skin cancers, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), malignant melanoma (MM), and nevus cell nevi (NCN). Our findings reveal that the frequency of TRPC5 expression in BCC is significantly lower compared to SCC and epidermal portions of NCN and MM. These results suggest that TRPC5 could serve as an immunohistochemical marker to distinguish SCC from BCC. Additionally, this study lays the groundwork for future research into the role of TRPC5 in tumor progression and metastasis, especially since BCCs, which rarely metastasize, are predominantly negative for TRPC5.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LACTIC-ACID; CALCIUM; RECEPTOR; CHEMORESISTANCE; TRPC5; skin tumors; melanoma; squamous cell carcinoma; basal cell carcinoma |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie Medicine > Lehrstuhl für Pathologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Sep 2026 05:24 |
| Last Modified: | 23 Sep 2026 05:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/66271 |
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