Michaelides, Ioannis and Bauernfeind, Stilla and Koelsch, Uwe and Hitzenbichler, Florian and Bohr, Christopher and Hintschich, Constantin A. (2025) Cervical Mycobacterium genavense infection in a patient with lymphadenitis and previously unknown anti-IFN-γ IgG autoantibodies. INFECTION, 53 (6). pp. 2889-2891. ISSN 0300-8126, 1439-0973
Full text not available from this repository. (Request a copy)Abstract
BackgroundInfections with atypical mycobacteria are rare and sometimes difficult to correctly diagnose. In many cases underlying diseases such immune deficiency can promote these infections.Case presentationA 43-year-old male of Southeast Asian origin presented to our tertiary care hospital with persistent cervical lymphadenopathy non-responsive to antibiotics. Imaging suggested malignancy, but a biopsy did not confirm this suspicion. PCR diagnostics identified Mycobacterium genavense and further immunological testing revealed an acquired adult-onset immunodeficiency due to neutralizing anti-IFN-gamma autoantibodies (nAIGA), explaining both the current infection and previous pleural empyema. The patient responded well to triple antimycobacterial therapy, with no recurrence or novel infection after almost two years.ConclusionsOur case highlights the importance of considering underlying immunodeficiencies and the patient's geographic origin in the diagnosis of rare infections.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTERFERON-GAMMA; <italic>Mycobacterium genavense</italic>; nAIGA; IL-2; IFN-gamma; Lymphadenitis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Sep 2026 06:10 |
| Last Modified: | 23 Sep 2026 06:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/66462 |
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