Dueker, Jonas and Petersen, Nele and Richter, Noah and Feuerer, Paul and Faber, Teresa and Hoelter, Niklas and Kehl, Niklas and Oboril, Jan and Strippel, Julian and Groeer, Alexander and Guimond, Nicolas and Kaldas, Sherif J. and Luebbesmeyer, Maximilian and Volpin, Giulio and Koenig, Burkhard and Hillenbrand, Julius (2025) Room-Temperature Copper Cross-Coupling Reactions of Anilines with Aryl Bromides. ORGANIC LETTERS, 27 (22). pp. 5566-5571. ISSN 1523-7060, 1523-7052
Full text not available from this repository. (Request a copy)Abstract
We present a novel copper-catalyzed method for aniline cross-couplings promoted by a 6-hydroxy picolinhydrazide ligand. The method achieves room-temperature reactivity with aryl bromides, enabled by a methanol/ethanol solvent mixture and a mild, functional group-compatible base, with catalyst loadings as low as 0.5 mol %. The use of industrially preferred solvents and base, as well as the high catalytic activity, offers a significant advancement in the practicality and scalability of industrial processes. Furthermore, the approach extends to the cross-coupling of aryl chlorides under elevated temperatures and demonstrates compatibility with additional nucleophile classes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | (HETERO)ARYL CHLORIDES; CATALYZED AMINATION; DIMETHYL-SULFOXIDE; N-ARYLATION; PALLADIUM; HALIDES; LIGAND; EFFICIENT; SOLVENT |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Jul 2026 09:04 |
| Last Modified: | 14 Jul 2026 09:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/66492 |
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