Pec, Jan and Fox, Henrik and Stadler, Stefan and Hetzenecker, Andrea and Oldenburg, Olaf and Koller, Michael and Zeman, Florian and Buchner, Stefan and Wagner, Stefan and Arzt, Michael (2025) Effect of adaptive servo-ventilation on circulating biomarkers in patients with sleep apnoea after myocardial infarction: results of an ancillary analysis of the randomised TEAM-ASV I trial. SLEEP MEDICINE, 133: 106620. ISSN 1389-9457, 1878-5506
Full text not available from this repository. (Request a copy)Abstract
Background: The Treatment of sleep apnoea Early After Myocardial infarction with Adaptive Servo-Ventilation (TEAM-ASV I) trial showed that adding adaptive servo-ventilation (ASV) to treat sleep-disordered breathing (SDB) early after acute myocardial infarction (AMI) improved myocardial salvage and decreased infarct size. It is purported that ASV may mitigate the inflammatory response, cardiac congestion, or fibrosis, but evidence supporting this assertion is sparse. Methods: This ancillary analysis of the multicentre, randomised, open-label TEAM-ASV I trial assessed patients with analysable blood samples at baseline and 12-week follow-up. Patients were randomised to early ASV treatment in addition to standard care for AMI and standard care alone (control). Changes in the levels of circulating biomarkers of inflammation (high-sensitivity C-reactive protein [hs-CRP], fibrinogen, interleukin [IL]-6, and interleukin-33 receptor [IL-33R]), fluid overload (N-terminal pro-B-type natriuretic peptide [NTproBNP] and antigen carbohydrate [CA]-125), and fibrosis (procollagen III type aminoterminal propeptide [PIIINP] and matrix metalloproteinase [MMP]-9) were compared between the ASV and control groups. Results: Forty SDB patients were analysed. The reduction in IL-33R was greater in the control group than in the ASV group (-1.94 [-3.88, 1.56] versus-4.30 [-6.46,-2.02] ng & sdot;ml-1). However, changes in other biomarkers of inflammation (hs-CRP, fibrinogen, and IL-6), fluid overload (NT-proBNP and CA-125), and fibrosis (PIIINP and MMP-9) were similar in both groups. Conclusions: This ancillary analysis of TEAM-ASV I does not support that treatment of SDB in the early phase after AMI with ASV has a clinically relevant short-term effect on biomarkers of inflammation, fluid overload, or fibrosis. Further studies are warranted to explain how early treatment with ASV results in increased myocardial salvage after AMI beyond the effects of SDB treatment on hemodynamics and oxygen demand-supply mismatch. Clinical trial registration: NCT02093377.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | III PROCOLLAGEN; HEART-FAILURE; TERMINAL PROPEPTIDE; PREVALENCE; Myocardial infarction; Sleep apnoea; Adaptive servo-ventilation; Circulating biomarkers |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Aug 2026 07:29 |
| Last Modified: | 11 Aug 2026 07:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/66556 |
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