Kaur, Jaspreet and Barham, Joshua P. (2025) Shedding Light on Synthetic Autocatalysis: From Conventional Closed-Shell Chemistries to Overlooked Open-Shell Occurrences. CHEMISTRY-A EUROPEAN JOURNAL. ISSN 0947-6539, 1521-3765
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Autocatalysis is a kinetic phenomenon where a reaction product catalyzes its own formation, often leading to sigmoidal reaction profiles and exponential rate acceleration. This process plays a fundamental role in biological systems, for example, in chemistry of the origins of life. Although synthetic reactions are not as widely reported as the biological studies, autocatalysis offers a unique mechanism and high efficiency to organic synthesis. This review highlights diverse synthetic examples in various autocatalytic mechanistic paradigms, including well-studied examples such as the Soai reaction. We also explore emerging examples in radical- and photochemistry-based systems, emphasizing recent advances in auto-photocatalysis. By exploring examples from different fields, this review aims to highlight the variety and potential of autocatalytic reactions for synthesis. We aim to encourage further research into autocatalysis as a powerful strategy for improving reaction efficiency, revealing new reaction pathways, and inspiring innovative catalytic methodologies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DIISOPROPYLAMIDE-MEDIATED ORTHOLITHIATION; ASYMMETRIC AUTOCATALYSIS; CURE KINETICS; OXIDATION; CATALYSIS; AMPLIFICATION; ACTIVATION; BEHAVIOR; PRODUCT; ACID; asymmetric amplification; autocatalysis; kinetics; photocatalysis; radicals |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 May 2026 04:32 |
| Last Modified: | 07 May 2026 04:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/66590 |
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