Das, Prithwa and Henriquez, Marco A. and Verdugo, Camilo and Sardana, Sunaina and Pattanaik, Aryaman and Jaque, Pablo and Cabrera, Alan R. and Reiser, Oliver (2025) 1,2-Aminosulfonylation of Alkenes via a Photoexcited Cu(I)-Substrate Complex: A Three-Component Coupling Approach. ACS CATALYSIS, 15 (21). pp. 17751-17758. ISSN 2155-5435
Full text not available from this repository. (Request a copy)Abstract
We report a Cu(I)-photocatalyzed three-component coupling process to achieve regioselective, vicinal 1,2-aminosulfonylations of alkenes. The critical aspect of this methodology is found in the utilization of in situ generated photoactive Cu(I)-amine substrate complexes, which facilitate the formal oxidation of Cu(I) to Cu(III) in a stepwise manner. In this way, the conceivable two-component chlorosulfonylation of alkenes is effectively suppressed, allowing the combination of styrene derivatives, sulfonyl chlorides, and amines. Furthermore, this protocol can be used to facilitate late-stage functionalization, thereby enabling the diversification of biomolecules.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSFER RADICAL-ADDITION; ATOM-TRANSFER; PHOTOREDOX CATALYSIS; DOUBLE-BONDS; COPPER; LIGHT; TRIETHYLBORANE; ALKYLATION; AMINES; APREMILAST; copper; photocatalysis; three-component couplings; ATRA reaction; substrate complex |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Aug 2026 04:50 |
| Last Modified: | 13 Aug 2026 04:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/66698 |
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