Rath, Anca and Mirzaliyeva, Nilufarbayim and Werner, Guido and Bender, Jennifer K. and Fischer, Martin A. and Cabal-Rosel, Adriana and Ruppitsch, Werner and Seth-Smith, Helena M. B. and Egli, Adrian and Hoertenhuber, Anna and Halabi, Milo and Salaheddin, Yarub and Prammer, Wolfgang and Kerschner, Heidrun and Hartl, Rainer and Ehrenschwender, Martin and Ambrosch, Andreas and Kalinowski, Joern and Klages, Levin Joe and Rueckert-Reed, Christian and Busche, Tobias and Kratzer, Alexander and Caplunik-Pratsch, Aila and Eichner, Anja and Fritsch, Juergen and Schneider-Brachert, Wulf and Kieninger, Baerbel (2025) Spread of the novel vancomycin-resistant Enterococcus faecium strain ST1299/vanA from local level in Germany to cross-border level in Austria, 2018 to 2022. EUROSURVEILLANCE, 30 (20): 2400389. ISSN 1025-496X, 1560-7917
Full text not available from this repository. (Request a copy)Abstract
Introduction: Vancomycin-resistant Enterococcus faecium (VREfm) isolates of sequence type (ST)1299 were described recently in south-eastern German hospitals and rapidly expanded from local to cross-border level. Aim: We describe the spread of the novel VREfm strain ST1299/vanA on a genetic, geographical and temporal level during the first 5 years after its detection. Methods: At University Hospital Regensburg (UHoR), routine VREfm surveillance is whole genome sequencing-based (>= 1 VREfm per van-genotype, patient and year). In this observational cohort study, we analysed one VREfm ST1299 isolate from our database (2016-2022) per patient and year. Isolates were added from the Hospital of the Merciful Brothers Regensburg (MBR), the National Reference Centre for Staphylococci and Enterococci (NRC), and clinical isolates from Austria. Results: We identified 635 VREfm ST1299 isolates (100% vanA), including 504 from Regensburg, and 113 blood cultures. ST1299 isolates were first detected in 2018 simultaneously in Regensburg (n = 2) and southern Bavaria (n = 2), with local (UHoR) and regional numbers increasing rapidly from 2020, shifting to national scale in the same year. Genome data, analysed by cgMLST, showed a predominance of ST1299/CT1903 (315/504 isolates, 62.5%) and ST1299/CT3109 (127/504 isolates, 25.2%) isolates from Regensburg. By 2021, ST1299/CT1903 reached Upper Austria causing hospital outbreaks (n = 5). Phylogeny analysis suggests common ancestors with VREfm ST80, ST18 and ST17. Conclusion: Since their emergence in 2018, two highly transmissible subtypes of ST1299/vanA reached national, then cross-border scale. The observed outbreak tendency may explain the rapid and successful spread and the high clonality in our collection.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SEQUENCE TYPING SCHEME; EPIDEMIOLOGY |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Krankenhaushygiene und Infektiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 May 2026 06:41 |
| Last Modified: | 07 May 2026 06:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/66835 |
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