Cold argon plasmas for non-enzymatic digestion of macromolecules

McGill, Daniel and Simon, Daniel and Ramadurai, Siva and Green, Felicia and Takats, Zoltan (2026) Cold argon plasmas for non-enzymatic digestion of macromolecules. CHEMICAL COMMUNICATIONS, 62. pp. 2896-2899. ISSN 1359-7345, 1364-548X

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Abstract

We have developed surface treatment techniques utilising radiofrequency current cold argon plasmas (RF-CAP) for non-enzymatic digestion of macromolecules, exemplified here with peptides and proteins of varying sizes. These plasmas are able to rapidly digest condensed-phase macromolecules with minimal sample preparation, producing predictable fragments visible by LC-MS analysis.

Item Type: Article
Uncontrolled Keywords: ELECTRON-CAPTURE DISSOCIATION; MASS-SPECTROMETRY; THERMAL DECOMPOSITION/DIGESTION; PROTEINS; PEPTIDE
Subjects: 500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Depositing User: Dr. Gernot Deinzer
Date Deposited: 05 May 2026 06:56
Last Modified: 05 May 2026 06:56
URI: https://pred.uni-regensburg.de/id/eprint/66863

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