Puljic, Anto and Frank, Konstantin and Cohen, Joel and Otto, Karine and Mayr, Josef and Hugh-Bloch, Andreas and Kuroki-Hasenoehrl, David (2025) A Scientific Framework for Comparing Hyaluronic Acid Filler Crosslinking Technologies. GELS, 11 (7): 487. ISSN 2310-2861
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Hyaluronic acid (HA) dermal fillers represent a cornerstone of modern esthetic medicine, providing a minimally invasive solution for facial volume restoration and skin rejuvenation. However, the diversity of available products, each utilizing distinct crosslinking technologies, presents a challenge for objective comparison and clinical decision making. This study introduces a scientific framework to evaluate and categorize the physicochemical properties of HA fillers based on two key parameter groups: dynamic parameters (e.g., rheology and gel content) and consistency parameters (e.g., extrusion force, water uptake, and gel particle size). Using standardized methodologies, 23 commercially available fillers from five major manufacturers were analyzed, enabling cross-technology comparisons. The findings reveal how specific crosslinking approaches influence the rheological behavior, handling characteristics, and potential clinical applications. By offering an integrated and reproducible assessment, this work helps practitioners select the most suitable filler for individualized treatment plans and encourages manufacturers to enhance product transparency through harmonized testing protocols.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SOFT-TISSUE FILLERS; RHEOLOGICAL PROPERTIES; BIOPHYSICAL CHARACTERISTICS; hyaluronic acid filler; rheology; gel content; gel particle size; extrusion force; physicochemical properties |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Jun 2026 08:13 |
| Last Modified: | 10 Jun 2026 08:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/66991 |
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