Boselli, Monica Fiorenza and Ghosh, Indrajit and Intini, Niccolo and Fattalini, Marco and Puglisi, Alessandra and Koenig, Burkhard and Benaglia, Maurizio (2025) Visible-Light Photoredox Catalytic Direct N-(Het)Arylation of Lactams. CHEMISTRY-A EUROPEAN JOURNAL, 31 (18): e202404385. ISSN 0947-6539, 1521-3765
Full text not available from this repository. (Request a copy)Abstract
Lactam rings are essential structural motifs in organic chemistry, widely present in natural products and clinically important drugs, such as antibiotics and antiepileptics. Existing methods for synthesizing N-functionalized lactams often require harsh conditions, toxic reagents, or complex catalytic systems. Here, we report a mild and efficient photochemical approach for generating N-centered radicals, enabling straightforward N-heteroarylation of lactams. This versatile method enables the synthesis of a range of N-(het)arylated lactams and is effective even in aqueous media, facilitating the functionalization of biomolecules. Furthermore, the photochemical reaction is easily scalable under continuous flow conditions, making it highly suitable for large-scale applications.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NITROGEN-RADICAL PRECURSORS; N-ARYLATION; ARENES; AMIDATION; SALTS; GAMMA; Flow Chemistry; Lactams; Photocatalysis; Radical Reactions |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 May 2026 04:43 |
| Last Modified: | 07 May 2026 04:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67017 |
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