Fermani, Federica and Chang, Simon and Mastrodicasa, Ylenia and Peters, Christian and Gaitanos, Louise and Morales, Pilar L. Alcala and Ramakrishnan, Charu and Deisseroth, Karl and Klein, Ruediger (2025) Food and water intake are regulated by distinct central amygdala circuits revealed using intersectional genetics. NATURE COMMUNICATIONS, 16 (1): 3072. ISSN 2041-1723
Full text not available from this repository. (Request a copy)Abstract
The central amygdala (CeA) plays a crucial role in defensive and appetitive behaviours. It contains genetically defined GABAergic neuron subpopulations distributed over three anatomical subregions, capsular (CeC), lateral (CeL), and medial (CeM). The roles that these molecularly- and anatomically-defined CeA neurons play in appetitive behavior remain unclear. Using intersectional genetics in mice, we found that neurons driving food or water consumption are confined to the CeM. Separate CeM subpopulations exist for water only versus water or food consumption. In vivo calcium imaging revealed that CeMHtr2a neurons promoting feeding are responsive towards appetitive cues with little regard for their physical attributes. CeMSst neurons involved in drinking are sensitive to the physical properties of salient stimuli. Both CeM subtypes receive inhibitory input from CeL and send projections to the parabrachial nucleus to promote appetitive behavior. These results suggest that distinct CeM microcircuits evaluate liquid and solid appetitive stimuli to drive the appropriate behavioral responses.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INHIBITORY CIRCUIT; EXPRESSING NEURONS; NUCLEUS; MEDIATE; RECOMBINATION; CONSUMPTION; MODULATION; BEHAVIOR; COMPLEX; CORTEX |
| Subjects: | 500 Science > 570 Life sciences 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Molecular and Cellular Neurobiology (Prof. Dr. Peter J. Flor) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jul 2026 07:05 |
| Last Modified: | 28 Jul 2026 07:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67156 |
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