Roemer, Nele and Gaebler, Arnim Johannes and Neuner, Irene and Haen, Ekkehard and Hiemke, Christoph and Schoretsanitis, Georgios and Paulzen, Michael (2025) Effects of the augmentation with quetiapine or olanzapine on the metabolism of duloxetine: a retrospective analysis. EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 18 (5). pp. 297-303. ISSN 1751-2433, 1751-2441
Full text not available from this repository. (Request a copy)Abstract
BackgroundIn antidepressant augmentation strategies, olanzapine or quetiapine are often concomitantly administered to duloxetine. The use of the same enzymes for the degradation of the drugs may lead to clinically relevant drug-drug-interactions, DDIs. So far, DDIs between olanzapine or quetiapine and duloxetine have only been studied in rats or in small numbers of patients.MethodsOut of a large therapeutic drug monitoring (TDM) database of duloxetine concentrations, three matched study groups were considered to investigate potential DDIs: a group of patients co-medicated with olanzapine (n = 81), a group co-medicated with quetiapine (n = 105) and a control group receiving only duloxetine (n = 105).ResultsNeither in the olanzapine group, nor in the quetiapine group, duloxetine plasma concentrations or dose-adjusted plasma concentrations differed significantly from the control group (p = 0.6759; p = 0.5841). The proportion of patients within the so-called therapeutic reference range was similar in all three groups (p = 0.635). However, smokers showed by 30% lower duloxetine plasma concentrations (p = 0.0179) and 32.5% lower dose-adjusted concentrations (p = 0.0003) compared to nonsmokers.ConclusionOur findings indicate that the combination of duloxetine and olanzapine or quetiapine is - from a pharmacokinetic view - a safe treatment option. TDM should be applied in case of co-medications to enhance therapeutic effectiveness and patients' safety.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MAJOR DEPRESSIVE DISORDER; NEWER ANTIDEPRESSANTS; CONSENSUS GUIDELINES; REUPTAKE INHIBITOR; DOUBLE-BLIND; PLACEBO; PHARMACOKINETICS; CYP2D6; NEUROPSYCHOPHARMACOLOGY; PHARMACOVIGILANCE; Therapeutic drug monitoring; KONBEST; duloxetine; quetiapine; olanzapine; pharmacokinetics; cytochrome; interaction |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehreinheit Pharmakologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Sep 2026 08:50 |
| Last Modified: | 23 Sep 2026 08:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67185 |
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