Ghanem, Rosy and Youf, Raphaelle and Haute, Tanguy and Buin, Xavier and Riool, Martijn and Pourchez, Jeremie and Montier, Tristan (2025) The (re)emergence of aerosol delivery: Treatment of pulmonary diseases and its clinical challenges. JOURNAL OF CONTROLLED RELEASE, 379. pp. 421-439. ISSN 0168-3659, 1873-4995
Full text not available from this repository. (Request a copy)Abstract
Aerosol delivery represents a rapid and non-invasive way to directly reach the lungs while escaping the hepatic first-pass effect. The development of pulmonary drugs for respiratory diseases such as cystic fibrosis, lung infections, pulmonary fibrosis or lung cancer requires an enhanced understanding of the relationships between the natural physiology of the respiratory system and the pathophysiology of these conditions. This knowledge is crucial to better predict and thereby control drug deposition. Moreover, aerosol administration faces several challenges, including the pulmonary tract, immune system, mucociliary clearance, the presence of fluid on the airway surfaces, and, in some cases, bacterial colonisation. Each of them directly influences on the bioavailability of the active molecule. In addition to these challenges, particle size and the device used to administer the treatment are critical factors that can significantly impact the biodistribution of the drugs. Nanoparticles are very promising in the development of new formulations for aerosol drug delivery, as they can be fine-tuned to reach the entire pulmonary tract and overcome the difficulties encountered along the way. However, to properly assess drug delivery, preclinical studies need to be more thorough to efficiently enhance drug delivery.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VIBRATING-MESH NEBULIZER; INHALED AZTREONAM LYSINE; CYSTIC-FIBROSIS SPUTUM; MEDIATED GENE-TRANSFER; PSEUDOMONAS-AERUGINOSA; DRUG-DELIVERY; LUNG-CANCER; EXTRACELLULAR VESICLES; IN-VIVO; THERAPEUTIC EFFECTIVENESS; Aerosol delivery; Nanoparticles; Gene therapy; Vaccines; Anti-microbial; Aerosol devices |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Jun 2026 05:50 |
| Last Modified: | 18 Jun 2026 05:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67236 |
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