Alizadeh Bahmani, Amir Hossein and Abdel-Aziz, Mahmoud I. and Hashimoto, Simone and Bang, Corinna and Brandstetter, Susanne and Corcuera-Elosegui, Paula and Franke, Andre and Gorenjak, Mario and Harner, Susanne and Kheiroddin, Parastoo and Lopez-Fernandez, Leyre and Neerincx, Anne H. and Pino-Yanes, Maria and Potocnik, Uros and Sardon-Prado, Olaia and Toncheva, Antoaneta A. and Wolff, Christine and Kabesch, Michael and Kraneveld, Aletta D. and Vijverberg, Susanne J. H. and Maitland-van der Zee, Anke H. and SysPharmPediA consortium, (2025) Association of Corticosteroid Inhaler Type with Saliva Microbiome in Moderate-to-Severe Pediatric Asthma. BIOMEDICINES, 13 (1): 89. ISSN , 2227-9059
Full text not available from this repository. (Request a copy)Abstract
Background/Objectives: Metered-dose inhalers (MDIs) and dry powder inhalers (DPIs) are common inhaled corticosteroid (ICS) inhaler devices. The difference in formulation and administration technique of these devices may influence oral cavity microbiota composition. We aimed to compare the saliva microbiome in children with moderate-to-severe asthma using ICS via MDIs versus DPIs. Methods: Saliva samples collected from 143 children (6-17 yrs) with moderate-to-severe asthma across four European countries (The Netherlands, Germany, Spain, and Slovenia) as part of the SysPharmPediA cohort were subjected to 16S rRNA sequencing. The microbiome was compared using global diversity (alpha and beta) between two groups of participants based on inhaler devices (MDI (n = 77) and DPI (n = 65)), and differential abundance was compared using the Analysis of Compositions of Microbiomes with the Bias Correction (ANCOM-BC) method. Results: No significant difference was observed in alpha-diversity between the two groups. However, beta-diversity analysis revealed significant differences between groups using both Bray-Curtis and weighted UniFrac methods (adjusted p-value = 0.015 and 0.044, respectively). Significant differential abundance between groups, with higher relative abundance in the MDI group compared to the DPI group, was detected at the family level [Carnobacteriaceae (adjusted p = 0.033)] and at the genus level [Granulicatella (adjusted p = 0.021) and Aggregatibacter (adjusted p = 0.011)]. Conclusions: Types of ICS devices are associated with different saliva microbiome compositions in moderate-to-severe pediatric asthma. The causal relation between inhaler types and changes in saliva microbiota composition needs to be further evaluated, as well as whether this leads to different potential adverse effects in terms of occurrence and level of severity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COPD; PERIODONTITIS; asthma; inhaled corticosteroids; metered-dose inhaler; dry powder inhaler; microbiome; saliva |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jul 2026 08:35 |
| Last Modified: | 28 Jul 2026 08:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67326 |
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