Nothofer, Stefanie and Haselbeck-Koebler, Michael and Zeitlinger, Markus and Dorn, Christoph and Petroff, David and Wrigge, Hermann and Dumps, Christian and Heller, Axel R. and Simon, Philipp (2025) Surgical Antibiotic Prophylaxis Dosing in Adult Patients with Obesity: A Comprehensive Review of Pharmacokinetic and Pharmacodynamic Data. ANESTHESIOLOGY, 142 (5). pp. 929-948. ISSN 0003-3022, 1528-1175
Full text not available from this repository. (Request a copy)Abstract
Surgical antibiotic prophylaxis is an important measure to prevent postoperative surgical site infections. Current guideline recommendations do not treat obesity specifically, although it can affect pharmacokinetics and pharmacodynamics. The objective of this review was to synthesize current evidence on the need for obesity-related dosing adjustments in surgical antibiotic prophylaxis. MEDLINE and Cochrane Library were searched for studies investigating antibiotic prophylaxis dosing in surgical patients with obesity. Outcomes of interest were pharmacokinetic parameters such as plasma and interstitial fluid concentrations, area under the concentration time curve in plasma and in interstitial fluid, and other pharmacokinetic measures. Thirty studies investigating cefazolin, cefoxitin, cefuroxime, piperacillin/tazobactam, meropenem, ertapenem, metronidazole, vancomycin, ciprofloxacin, and gentamicin were included in this analysis. Except for metronidazole, cefoxitin, and gentamicin, there is currently no evidence suggesting the need for dosing adjustments.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SITE INFECTIONS; MORBIDLY OBESE; TISSUE CONCENTRATIONS; CESAREAN DELIVERY; BARIATRIC SURGERY; POPULATION PHARMACOKINETICS; ANTIMICROBIAL PROPHYLAXIS; RISK-FACTORS; CEFAZOLIN; WEIGHT |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Group Clinical Pharmacy (Dr. Dorn) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Oct 2026 07:27 |
| Last Modified: | 13 Oct 2026 07:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67342 |
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