Ries, Clemens and Stark, Tibor and Boulat, Benoit and Ruhwedel, Torben and Delling, Jan Philipp and Infante, Antonio Miralles and von Poblotzki, Julia T. and Ulivi, Alessandro and von Mucke-Heim, Iven-Alex and Chang, Simon and Sakimura, Kenji and Itoi, Keiichi and Nestvogel, Dennis B. and Attardo, Alessio and Czisch, Michael and Nave, Klaus-Armin and Mobius, Wiebke and Dimou, Leda and Deussing, Jan M. (2025) Neuropeptide CRH prevents premature differentiation of OPCs following CNS injury and in early postnatal development. CELL REPORTS, 44 (11): 116474. ISSN 2639-1856, 2211-1247
Full text not available from this repository. (Request a copy)Abstract
The role of neuropeptides and their receptors in oligodendrocyte (OL) progenitor cells (OPCs) has been largely overlooked so far. Here, we describe a new subpopulation of corticotropin-releasing hormone (CRH)-expressing OPCs. Brain injury rapidly induces transient CRH expression in OPCs that aggregate around injury sites and exhibit an elevated capacity to differentiate into myelinating OLs. As target cells, we identified CRH receptor type 1 (CRHR1)-expressing OPCs, which show a decreased differentiation velocity. CRH/CRHR1 system inactivation increases the speed of OL generation but compromises their long-term survival after acute injury. Under non-injury conditions, CRH/CRHR1 system deficiency leads to increased early postnatal oligodendrogenesis and alterations in adult myelination. Altogether, we show that OPCderived CRH not only actively influences the injury environment through interaction with CRHR1-expressing OPCs but also identify the G-protein coupled receptor CRHR1 as a critical modulator of oligodendrogenesis during early postnatal development with lasting effects on adult myelination.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IMPAIRED STRESS-RESPONSE; PROGENITOR-CELL; NEURONS; BRAIN; OLIGODENDROCYTES; MICE; TRANSMISSION; MYELINATION; HORMONE; DEATH; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Molecular and Cellular Neurobiology (Prof. Dr. Peter J. Flor) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Jun 2026 11:42 |
| Last Modified: | 02 Jun 2026 11:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67393 |
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