Dyczko, Aleksandra and Corte-Real, Beatriz F. and Hamad, Ibrahim and Linker, Ralf A. and Kleinewietfeld, Markus (2025) Teriflunomide Inhibits Human FOXP3+ Regulatory T Cell Function by Interference With Mitochondrial Respiration. EUROPEAN JOURNAL OF IMMUNOLOGY, 55 (7): e51260. ISSN 0014-2980, 1521-4141
Full text not available from this repository. (Request a copy)Abstract
Regulatory FOXP3+ T cells (Tregs) have been characterized with unique metabolic demands, preferentially relying on fatty acid beta-oxidation (FAO) and oxidative phosphorylation (OXPHOS). Several studies have indicated that Treg mitochondrial fitness is crucial for maintaining their stability and suppressive activity with an emphasis on complex-III of the electron transport chain (ETC). Dysfunctional Tregs isolated from patients with autoimmunity like multiple sclerosis (MS) show diminished mitochondrial respiration and the induction of a T helper (Th)1-like phenotype, characterized by increased production of interferon (IFN)-gamma. Teriflunomide reduces the proliferation of activated T and B lymphocytes by inhibition of de novo pyrimidine synthesis, providing therapy for patients with autoimmune diseases. Recent data demonstrated that teriflunomide further inhibited complex-III activity in line with hampered mitochondrial respiration in T cells. Considering the essential role of OXPHOS and complex-III activity for Tregs, we therefore thought to investigate with this study the effects of teriflunomide on immunometabolism and function in human Tregs. Interestingly, teriflunomide impaired the mitochondrial function of human Tregs and further induced a Th1-like phenotype in line with defective suppressive activity. Our findings suggest that teriflunomide may potentially exert distinct effects on pro- versus anti-inflammatory T cell subsets, indicating the need for further detailed evaluation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | METABOLISM; autoimmunity; regulatory T cells; immunometabolism; multiple sclerosis; teriflunomide |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 May 2026 12:45 |
| Last Modified: | 28 May 2026 12:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67406 |
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