Lopez, Juanita Suzanne and Haefliger, Simon and Plummer, Ruth and Clement, Paul M. and Evans, Thomas R. Jeffry and Laubli, Heinz and Roth, Patrick and Kristeleit, Rebecca and Brazil, Lucy and Tabatabai, Ghazaleh and Wick, Antje and Wunderlich, Benjamin and Beebe, Kirk and Eisner, Joel Robert and Lane, Heidi and Engelhardt, Marc and Kaindl, Thomas and Hau, Peter and Hundsberger, Thomas and Steinbach, Joachim (2025) A phase 1/2a dose-finding study and biomarker assessment of oral lisavanbulin in patients with high-grade glioma or glioblastoma. CELL REPORTS MEDICINE, 6 (6): 102165. ISSN 2666-3791,
Full text not available from this repository. (Request a copy)Abstract
Lisavanbulin is a prodrug of the microtubule-targeting agent avanbulin. Both avanbulin and lisavanbulin have demonstrated significant antitumor activity in several preclinical tumor models including glioblastoma. Previous human studies demonstrated that 48-h infusions of intravenous lisavanbulin were well tolerated with preliminary activity in recurrent glioblastoma. The current phase 1/2a study evaluates the safety and tolerability of once-daily oral lisavanbulin in patients with solid tumors or recurrent glioblastoma or high-grade glioma. Lisavanbulin is associated with profound, durable responses in a subset of patients with recurrent refractory grade 4 astrocytoma or glioblastoma. We present here the clinical and translational results from this trial, including a description of a response-predictive molecular signature that warrants further exploration in these tumor types of significant unmet need. The study is registered at ClinicalTrials.gov (NCT02490800).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TARGETING TUMOR; BAL101553; AGENT; TUBULIN; MICROTUBULES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 May 2026 06:13 |
| Last Modified: | 19 May 2026 06:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67467 |
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