Strantz, Cosima and Boehm, Dominik and Ganslandt, Thomas and Boerries, Melanie and Metzger, Patrick and Pauli, Thomas and Blaumeiser, Andreas and Scheiter, Alexander and Jung, Ian-Christopher and Christoph, Jan and Manuilova, Iryna and Strauch, Konstantin and Ustjanzew, Arsenij and Reimer, Niklas and Busch, Hauke and Unberath, Philipp (2025) Empowering personalized oncology: evolution of digital support and visualization tools for molecular tumor boards. BMC MEDICAL INFORMATICS AND DECISION MAKING, 25 (1): 29. ISSN , 1472-6947
Full text not available from this repository. (Request a copy)Abstract
BackgroundMolecular tumor boards (MTBs) play a pivotal role in personalized oncology, leveraging complex data sets to tailor therapy for cancer patients. The integration of digital support and visualization tools is essential in this rapidly evolving field facing fast-growing data and changing clinical processes. This study addresses the gap in understanding the evolution of software and visualization needs within MTBs and evaluates the current state of digital support. Alignment between user requirements and software development is crucial to avoid waste of resources and maintain trust.MethodsIn two consecutive nationwide medical informatics projects in Germany, surveys and expert interviews were conducted as stage 1 (n = 14), stage 2 (n = 30), and stage 3 (n = 9). Surveys, via the SoSci Survey tool, covered participants' roles, working methods, and support needs. The second survey additionally addressed requirements for visualization solutions in molecular tumor boards. These aimed to understand diverse requirements for preparation, implementation, and documentation. Nine semi-structured expert interviews complemented quantitative findings through open discussion.ResultsUsing quantitative and qualitative analyses, we show that existing digital tools may improve therapy recommendations and streamline MTB case preparation, while continuous training and system improvements are needed.ConclusionsOur study contributes to the field by highlighting the importance of developing user-centric, customizable software solutions that can adapt to the fast-paced environment of MTBs to advance personalized oncology. In doing so, it lays the foundation for further advances in personalized medicine in oncology and points to a shift towards more efficient, technology-driven clinical decision-making processes. This research not only enriches our understanding of the integration of digital tools into MTBs, but also signals a broader shift towards technological innovation in healthcare.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CANCER GENOMICS; MEDICINE; SYSTEMS; NETWORK; TRIALS; CARE; Molecular tumor board; Personalized oncology; Precision medicine; Genomics; Annotation; Clinical decision support systems; Visualization; cBioPortal; Requirements analysis; User-centered design |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 May 2026 09:11 |
| Last Modified: | 11 May 2026 09:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67507 |
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