Sarrible, Gisela Belen and Bazzano, Maria Victoria and Koutsovitis, Caterina and Bilbao, Maria Guillermina and Da Cuna, Rodrigo Hernan and Neira, Melanie and Bartolome, Julian Alberto and Elia, Evelin Mariel (2025) Effects of coenzyme q10 supplementation on metabolic and reproductive outcomes in obese rats. JOURNAL OF OVARIAN RESEARCH, 18 (1): 22. ISSN , 1757-2215
Full text not available from this repository. (Request a copy)Abstract
Obesity, a global epidemic, is linked to adverse reproductive outcomes, including infertility and ovulation dysfunction. The cafeteria diet (CAF) serves as an animal model mirroring Western diet habit. Coenzyme Q10 (CoQ10), known for enhancing reproductive outcomes in various pathologies, is not fully understood for its effects on obesity treatment. Here, obesity was modeled using CAF-fed rats to assess CoQ10's impact on metabolic and ovarian disruptions caused by obesity. Wistar rats were divided into control (standard diet) and obese (CAF diet) groups. After 75 days, half of each group received oral CoQ10 (5 mg/kg) for 13 days, while the rest received a vehicle. Animals were euthanized during the estrus phase, and blood and ovaries were collected for analysis. CAF caused increased body weight gain (p < 0.01) associated with hyperglycemia, hypertriglyceridemia, and hypercholesterolemia (p < 0.05). Moreover, it caused a reduction in the number of AMH + follicles (p < 0.001), increasing follicular atresia (p < 0.05) and serum estradiol levels (p < 0.05). Obesity also altered the estrous cycle and reduced the ovulation rate (p < 0.05). CoQ10 administration showed beneficial effects on all ovarian disruptions but had no effect on the metabolic alterations induced by obesity. In summary, CoQ10 could be an additional treatment for obesity-related infertility in patients with normal metabolic profiles. While CoQ10 does not affect metabolic parameters influenced by obesity, crucial for reproductive issues and offspring health, it is recommended as part of a treatment plan that includes a balanced diet and increased physical activity for obese individuals with metabolic alterations seeking pregnancy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DIET-INDUCED OBESITY; ANTI-MULLERIAN HORMONE; CAFETERIA DIET; MODEL; Q(10); STIMULATION; ASSOCIATION; ALTERS; TISSUE; LIVER; Obesity; Coenzyme Q10; Metabolism; Ovulation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Geburtshilfe) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Apr 2026 12:24 |
| Last Modified: | 23 Apr 2026 12:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67541 |
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