Grevenstein, David and Mamilos, Andreas and Schmitt, Volker H. and Babel, Maximilian and Rupp, Markus and Winter, Lina and Brochhausen, Christoph (2025) The plica syndrome in the knee - A histopathological pilot study. PATHOLOGY RESEARCH AND PRACTICE, 273: 156152. ISSN 0344-0338, 1618-0631
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The plica syndrome, a condition caused by hypertrophy of the medial plica in the knee, is clinically characterized by antero-medial knee pain, especially in sport activities involving repetitive joint extension and flexion. Despite its high prevalence in young individuals, it is often overlooked, and there is a lack of systematic examination regarding characteristic histopathological changes associated with this syndrome. We performed a retrospective histological evaluation using haematoxylin-eosin, Elastica van Gieson and Berlin-blue staining and correlated clinical data of 45 plicae obtained from patients diagnosed with symptomatic plica syndrome. Our analysis focused on identifying characteristic pathological changes, especially acute and chronic inflammatory signs. The majority of examined plicae showed signs of fibrosis. Chronic inflammatory reactions dominated over acute inflammatory reactions. Additionally, hypertrophy of the synovial covering cells was observed. Lymphocyte aggregation occurred, while bleeding and fatty tissue reorganisation were rare. Our findings suggest that inflammation plays an active role in the development and maintenance of the plica syndrome. Future studies should prioritize the development of a histopathological scoring system for plica syndrome and the question whether the plica syndrome represents a risk factor for osteoarthritis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MEDIAL PLICA; SYNOVIAL PLICAE; PATHOPHYSIOLOGY; DIAGNOSIS; PAIN; Plica; Plica syndrome; Shelf syndrome; Cartilage; Knee; Inflammation; Fibrosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Apr 2026 11:35 |
| Last Modified: | 23 Apr 2026 11:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/67572 |
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